N-([1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides

ABSTRACT

N-(Triazoloazinyl)arylsulfonamide compounds, such as 2,6-dimethoxy-N-(8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide, 2-methoxy-4-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridine-3-sulfonamide, and 2-methoxy-6-methoxycarbonyl-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzenesulfonamide were prepared from appropriately substituted 2-amino[1,2,4]triazolo[1,5-c]pyrimidine and 2-amino[1,2,4]triazolo[1,5-a]pyridine compounds and appropriately substituted benzenesulfonyl chloride and pyridine-3-sulfonyl chloride compounds. The compounds were found to be useful as herbicides.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a divisional of Ser. No. 08/936,046 filed Sep. 23, 1997 now U.S. Pat. No. 5,858,924 which claims the benefit of U.S. Provisional Application No. 60/026,556, filed Sep. 24, 1996.

BACKGROUND OF THE INVENTION

The present invention relates to substituted benzenesulfonamide and pyridinesulfonamide compounds, to herbicidal compositions containing the compounds, and to the utility of the compounds for the control of unwanted vegetation.

The control of unwanted vegetation by means of chemical agents, i.e., herbicides, is an important aspect of modern agriculture and land management. While many chemicals that are useful for the control of unwanted vegetation are known, new compounds that are more effective generally, are more effective for specific plant species, are less damaging to desirable vegetation, are safer to man or the environment, are less expensive to use, or have other advantageous attributes are desirable.

Many substituted benzenesulfonamide compounds are known and certain of them are known to possess herbicidal activity. For example, certain N-([1,2,4]triazolo,[5-a]pyrimidin-2-yl)benzenesulfonamide compounds and their herbicidal utility were disclosed in U.S. Pat. No. 4,638,075 and certain N-([1,2,4]triazolo[1,3,5]triazin-2-yl)benzenesulfonamide compounds were disclosed in U.S. Pat. No. 4,685,958. Certain N-phenyl arylsulfonamide compounds are also known and are known to possess herbicidal activity. For example, certain N-(substituted phenyl)[1,2,4]triazolo[1,5-c]pyrimidin-2-sulfonamide compounds were disclosed in U.S. Pat. No. 5,163,995 and certain N-(substituted phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-sulfonamide compounds were disclosed in U.S. Pat. No. 5,571,775, issued Nov. 5, 1996.

SUMMARY OF THE INVENTION

It has now been found that a class of novel N-(triazoloazinyl)arylsulfonamide compounds comprising N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide, N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridinesulfonamide, N-([1,2,4]triazolo[1,5-a]pyridin-2-yl)benzenesulfonamide, and N-([1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridinesulfonamide compounds are potent herbicides for the control of unwanted vegetation by either preemergence or postemergence application. Many of the compounds have desirable selectivity to valuable crops and have favorable toxicological and environmental attributes.

The invention includes N-(triazoloazinyl)arylsulfonamide compounds of Formula I: ##STR1## wherein X represents N or C--Y;

W represents O(C₁ -C₃ alkyl), Cl, Br, F, or H;

Y represents H, OCH₃, F, Cl, Br, I, or CH₃ optionally substituted with up to three fluorine atoms;

Z represents O(C₁ -C₃ alkyl), H, F, Cl, Br, I, S(C₁ -C₃ alkyl), or CH₃ optionally substituted with up to three fluorine atoms; with the proviso that at least one of W and Z represents O(C₁ -C₃ alkyl);

Q represents C--H or N;

A represents F, Cl, Br, or I, or CO₂ (C₁ -C₄ alkyl) or represents C₁ -C₃ alkyl, O(C₁ -C₄ alkyl), O(C₃ -C₄ alkeny), O(C₃ -C₄ alkynyl), or S(C₁ -C₃ alkyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms, or represents a 2-methyl-1,3-dioxolan-2-yl moiety, and, when Q represents N, H;

B represents H, F, Cl, Br, I, NO₂, CN, CO₂ (C₁ -C₄ alkyl), NH(C₁ -C₃ alkyl), or N(C₁ -C₃ alkyl)₂ or represents O(C₁ -C₄ alkyl), O(C₃ -C₄ alkenyl), O(C₃ -C₄ alkynyl), C₁ -C₃ alkyl, S(C₁ -C₃ alkyl), SO(C₁ -C₃ alkyl), SO₂ (C₁ -C₃ alkyl), S(C₃ -C₄ alkenyl), SO(C₃ -C₄ alkenyl), SO₂ (C₃ -C₄ alkenyl), S(C₃ -C₄ alkynyl), SO(C₃ -C₄ alkynyl), or SO₂ (C₃ -C₄ alkynyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms; with the proviso that A and B do not simultaneously represent H;

D represents H, F, Cl, Br, I, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ F, CHF₂, or CF₃ ; or B and D together represent a fragment of the formula O--CH₂ --O, optionally substituted with one or two F or CH₃ ;

T represents H, SO₂ R, C(O)R, C(O)OR, C(O)NR'₂, or CH₂ CH₂ C(O)OR;

R represents C₁ -C₄ alkyl, C₃ -C₄ alkenyl, or C₃ -C₄ alkynyl each optionally possessing up to two chloro, bromo, O(C₁ -C₄)alkyl, or phenyl substituents and up to the maximum possible number of fluoro substituents; and

R' represents H, C₁ -C₄ alkyl, C₃ -C₄ alkenyl, or C₃ -C₄ alkynyl;

and, when T represents H, the agriculturally acceptable salts thereof.

Compounds wherein X represents each of N and C--H and compounds wherein Q represents each of N and C--H are among the preferred compounds of the invention. Many of the preferred compounds of the invention possess a methoxy substituent in the 5-position (W) and a methoxy or halogen substituent in the 8-position (Z) of the triazoloazine ring. Some of the preferred compounds further possess an ortho methoxy substituent (A or B) in combination with a variety of substituents in the other ortho postiton (A or B) and hydrogen in the meta position; an ortho methoxy substituent (A) in combination with hydrogen or a meta methyl or chloro substituent (D) and no substituent in the other ortho position (B); or an ortho trifluoromethyl substituent (B) in combination with a variety of substituents in the other ortho postiton (A) and hydrogen in the meta position.

The invention further includes compositions containing herbicidal amounts of compounds of Formula I in combination with one or more agriculturally acceptable adjuvants or carriers and the use of the compounds of Formula I as herbicides. The use of suitable compounds of the invention to achieve either total vegetation control or the selective control of weeds in wheat, rice and oil-seed rape crops is generally preferred. Both grassy and broadleaf weeds can be controlled. Postemergence application of the compounds to undesirable vegetation is generally preferred.

DETAILED DESCRIPTION OF THE INVENTION

The N-(triazoloazinyl)arylsulfonamide compounds of the invention can generally be described as substituted N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide, N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridine-3-sulfonamide, N-([1,2,4]triazolo[1,5-a]pyridin-2-yl)benzenesulfonamide, and N-([1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridine-3-sulfonamide compounds. They can be characterized as substituted benzenesulfonamide and pyridine-3-sulfonamide compounds possessing, on the amide nitrogen atom, a substituted [1,2,4]triazolo[1,5-c]pyrimidin-2-yl or substituted [1,2,4]triazolo[1,5-a]pyridin-2-yl moiety.

The herbicidal compounds of the invention are N-(triazoloazinyl)arylsulfonamide compounds of generic Formula I: ##STR2## Such compounds in which X represents N contain a substituted N-([1,2,4]triazolo[1,5-c]pyrimidin-2-yl) moiety and those in which X represents C--Y contain a substituted N-([1,2,4]triazolo[1,5-a]pyridin-2-yl) moiety. Compounds in which Q represents N are pyridinesulfonamide compounds and compounds in which Q represents C--H are benzenesulfonamide compounds. The compounds are further characterized by possessing a C₁ -C₃ alkoxy substituent in one or both of the 5- and 8-positions (W and Z, respectively) of the triazoloazine ring and by possessing at least one ortho substituent (A) on the phenyl or pyridine ring.

The compounds of the invention include compounds of Formula I wherein X represents N or C--Y (wherein Y represents hydrogen, a halogen, methoxy, or methyl optionally substituted with up to three fluorine atoms). Compounds wherein X represents N are often preferred. Compounds wherein X represents C--H, however, are sometimes preferred. The compounds of the invention include compounds of Formula I wherein Q represents N or C--H. Each of these two options is sometimes preferred. Under many circumstances, compounds wherein X represents N and Q represents C--H are preferred but, under other circumstances, compounds wherein both X and Q represent N are preferred. On the other hand, under some circumstances, compounds wherein X represents C--Y and Q represents C--H are preferred.

The triazoloazine ring of the compounds of Formula I is at least mono substituted. The compounds of the invention include those wherein W represents methoxy, ethoxy, propoxy, 1-methylethoxy, cyclopropoxy, fluoro, chloro, bromo, or hydrogen and wherein Z represents methoxy, ethoxy, propoxy, 1-methylethoxy, cyclopropoxy, methylthio, ethylthio, 1-methylethylthio, cyclopropylthio, hydrogen, fluoro, chloro, bromo, iodo, or methyl optionally substituted with up to three fluorine atoms, with the proviso that at least one of W and Z represents one of the specified alkoxy moieties. Compounds wherein one of W and Z represents alkoxy, the other represents fluoro, chloro, bromo, methyl, methoxy, or ethoxy, and X represents N or C--H are often preferred. Such compounds wherein one or both of W and Z represents methoxy are often more preferred. Compounds of Formula I wherein W represents methoxy and Z represents methoxy, chloro, or bromo are often most preferred. Such compounds wherein X represents N are sometimes of special interest as are such compounds wherein X represents C--H and Z represents specifically methoxy.

The compounds of Formula I wherein Q represents C--H include those wherein A represents a halogen or (C₁ -C₄ alkoxy)carbonyl or represents C₁ -C₃ alkyl, C₁ -C₄ alkoxy, C₃ -C₄ alkenoxy, C₃ -C₄ alkynoxy, or C₁ -C₃ alkylthio each of which is optionally substituted with one C₁ -C₃ alkoxy, C₁ -C₃ alkylthio, chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms. A may also represent a 2-methyl-1,3-dioxolan-2-yl moiety. When Q represents N, the compounds of Formula I also include those wherein A represents hydrogen. Methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, 1-(fluoromethyl)-2-fluoroethoxy, trifluoromethoxy, chloro, and fluoro are often preferred. Methoxy, ethoxy, propoxy, or 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, and 1-(fluoromethyl)-2-fluoroethoxy are often more preferred. Methoxy is sometimes of special interest.

The compounds of Formula I further include those wherein B represents hydrogen, a halogen, nitro, cyano, (C₁ -C₄ alkoxy)carbonyl, C₁ -C₃ alkylamino, or di(C₁ -C₃ alkyl)amino or represents C₁ -C₃ alkyl, C₁ -C₄ alkoxy, C₃ -C₄ alkenoxy, C₃ -C₄ alkynoxy, C₁ -C₃ alkylthio, C₁ -C₃ alkanesulfinyl, C₁ -C₃ alkanesulfonyl, C₃ -C₄ alkenylthio, C₃ -C₄ alkenesulfinyl, C₃ -C₄ alkenesulfonyl, C₃ -C₄ alkynylthio, C₃ -C₄ alkynesulfinyl, or C₃ -C₄ alkynesulfonyl each of which is optionally substituted with one C₁ -C₃ alkoxy, C₁ -C₃ alkylthio, chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms. Such compounds wherein Q represents N and both A and B represent hydrogen are, however, excluded. Thus, whether Q represents N or C--H, at least one of A and B represents a substituent other than hydrogen. Hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethyl, methylthio, methyl, trifluoromethyl, trifluoromethoxy, fluoro, chloro, and methoxycarbonyl, are often preferred B substituents. Hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethyl, trifluoromethyl, fluoro, chloro, or methoxycarbonyl are typically more preferred when Q represents C--H and hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, trifluoromethyl, and methoxycarbonyl are more preferred when Q represents N. Methoxy and trifluoromethyl are often, independently, B substituents of special interest.

The compounds of the invention still further include those wherein D represents hydrogen, a halogen, methyl, ethyl, 1-methylethyl, propyl, methoxy, ethoxy, fluoromethyl, difluoromethyl, or trifluoromethyl. They further include compounds wherein B and D together represent a methylenedioxy fragment optionally substituted with one or two fluorine or methyl groups. Compounds wherein D represents hydrogen, fluoro, bromo, chloro, or methyl are typically preferred. Compounds wherein D represents hydrogen, chloro, or methyl are often more preferred when Q represents C--H while those wherein D represents hydrogen or methyl more typically more preferred when Q represents N.

Compounds of Formula I wherein A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, 1-(fluoromethyl)-2-fluoroethoxy, trifluoromethoxy, chloro, or fluoro; B represents hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethyl, methylthio, methyl, trifluoromethyl, trifluoromethoxy, fluoro, chloro, or methoxycarbonyl; and D represents hydrogen, fluoro, chloro, bromo, or methyl are often preferred. Such compounds wherein B represents methoxy and D represents hydrogen; wherein A represents methoxy and D represents hydrogen, methyl, or chloro; and wherein B represents trifluoromethyl and D represents hydrogen are often of special interest.

Compounds of Formula I wherein Q represents C--H and one or both of B and D represent hydrogen are often preferred. Compounds wherein Q represents C--H and A represents methoxy, ethoxy, propoxy, or 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, or 1-(fluoromethyl)-2-fluoroethoxy; B represents hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethyl, trifluoromethyl, fluoro, chloro, or methoxycarbonyl; and D represents hydrogen, chloro, or methyl are often more preferred. Such compounds wherein D represents hydrogen and either A and B each represent methoxy or A represents methoxy and B represents trifluoromethyl or methoxycarbonyl and are sometimes independently of interest. Compounds wherein Q represents C--H and A represents methoxy, ethoxy, propoxy, or 1-methylethoxy, B represents hydrogen; and D represents chloro or methyl are sometimes preferred.

Compounds of Formula I wherein Q represents N and A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, or 1-(fluoromethyl)-2-fluoroethoxy; B represents hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, trifluoromethyl, or methoxycarbonyl; and D represents hydrogen or methyl are typically preferred. Compounds wherein B represents trifluoromethyl and A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, or 1-(fluoromethyl)-2-fluoroethoxy; and D represent hydrogen are typically more preferred.

The compounds of Formula I include those wherein T represents hydrogen, an alkylsulfonyl group (SO₂ R), an acyl group (C(O)R), an alkoxycarbonyl group (C(O)OR), an aminocarbonyl group (C(O)NR'₂), or a 2-(alkoxycarbonyl)ethyl group (CH₂ CH₂ C(O)OR), wherein R represents C₁ -C₄ alkyl, C₃ -C₄ alkenyl, or C₃ -C₄ alkynyl each optionally possessing up to two chloro, bromo, C₁ -C₄ alkoxy, or phenyl substituents and up to the maximum possible number of fluoro substituents and R' represents H, C₁ -C₄ alkyl, C₃ -C₄ alkenyl, or C₃ -C₄ alkynyl. Such compounds wherein T represents hydrogen are preferred. The invention further includes the agriculturally acceptable salts of compounds of the Formula I wherein T represents hydrogen.

Compounds of Formula I which possess each possible combination of preferred, more preferred, most preferred, desirable, and special interest substituents are, further, considered to be important embodiments of the invention.

The terms alkyl, alkenyl, and alkynyl (including when modified as in haloalkyl and alkoxy) as used herein include straight chain, branched chain, and cyclic groups. Thus, typical alkyl groups are methyl, ethyl, 1-methylethyl, propyl, 1,1-dimethylethyl, and cyclopropyl. Methyl and ethyl are often preferred. Alkyl groups are sometimes referred to herein as normal (n), iso (i), or secondary (s). Typical alkyl with up to the maximum possible number of fluoro substituents include trifluoromethyl, monofluoromethyl, 2,2,2-trifluoroethyl, 2,3-difluoropropyl, and the like; trifluoromethyl is often preferred. The term halogen includes fluorine, chlorine, bromine, and iodine.

The term "agriculturally acceptable salts" is employed herein to denote compounds wherein the acidic sulfonamide proton of the compound of Formula I is replaced by a cation which itself is neither herbicidal to crop plants being treated nor significantly deleterious to the applicator, the environment, or the ultimate user of any crop being treated. Suitable cations include, for example, those derived from alkali or alkaline earth metals and those derived from ammonia and amines. Preferred cations include sodium, potassium, magnesium, and aminium cations of the formula:

    R.sup.6 R.sup.7 R.sup.8 NH+

wherein R⁶, R⁷, and R⁸ each, independently represents hydrogen or (C₁ -C₁₂)alkyl, (C₃ -C₁₂)cycloalkyl, or (C₃ -C₁₂)alkenyl, each of which is optionally substituted by one or more hydroxy, (C₁ -C₈)alkoxy, (C₁ -C₈)alkylthio or phenyl groups; provided that R⁶, R⁷, and R⁸ are sterically compatible. Additionally, any two of R⁶, R⁷, and R⁸ together may represent an aliphatic difunctional moiety containing 1 to 12 carbon atoms and up to two oxygen or sulfur atoms. Salts of the compounds of Formula I can be prepared by treatment of compounds of Formula I wherein V represents hydrogen with a metal hydroxide, such as sodium hydroxide, potassium hydroxide, or magnesium hydroxide, or an amine, such as ammonia, trimethylamine, hydroxyethylamine, bisallylamine, 2-butoxyethylamine, morpholine, cyclododecylamine, or benzylamine.

The compounds of Table I are examples of the compounds of the invention. Some of the specifically preferred compounds of Formula I, which vary depending on the weed species to be controlled, the crop present (if any), and other factors, include the following compounds of Table 1: 1, 2, 10, 13, 14, 15, 18, 21, 23, 26, 27, 28, 32, 34, 36, 37, 38, 39, 41, 43, 46, 50, 52, 53, 54, 55, 60, 63, 65, 77, 80, 81, 92, 95, 96, 98, 105, 106, 109, 120, 122, 126, 139, 142, 167, 177, 184, 185, 187, 188, 190, 194, 195, 203, 208, 210, and 220. The following compounds are sometimes more preferred: 2-methoxy-6-(trifluoromethyl)-N-(8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 34), 2,6-dimethoxy-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 36), 2-methoxy-6-methoxycarbonyl-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzenesulfonamide (cpd. 98), 2-methoxy-5-methyl-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 105), 5-chloro-2-methoxy-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 106), and 2-methoxy-6-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)pyridine-3-sulfonamide (cpd. 142), 2-(2-fluoroethoxy)-6-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 167), 2-(2-chloroethoxy)-6-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 203), 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 190), and 2-(1-fluoromethyl-2-fluoroethoxy)-6-(trifluoromethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide (cpd. 187).

                                      TABLE 1                                      __________________________________________________________________________     SULFONAMIDE COMPOUNDS                                                            #STR3##                                                                         -                                                                                                                           Melting                                                                             Elem. Anal.                 Cpd.          Point, Calc./Found                                             No.                                                                               X    W   Z   T     Q  A       B     D   Form ° C.                                                                         % C % H                                                                               % N                __________________________________________________________________________     1  N    OCH.sub.3                                                                          F   H     C--H                                                                              Cl      H     H   white                                                                               184-185                                                                             40.3                                                                               2.54                                                                              19.6                          powder  40.4 2.43 19.4                                                2 N OCH.sub.3 F H C--H F H H white 226-228 42.2 2.66 20.5                               powder  42.4 2.43 20.2                                                3 N OCH.sub.3 F H C--H CO.sub.2 CH.sub.3 H H white 175-177 44.1 3.17                                                                     18.4                          powder  43.9 2.96 18.2                                                4 N OCH.sub.3 F H C--H CF.sub.3 H H white 185-187 39.9 2.32 17.9                                                                         powder  40.2                                                                   2.19 17.7                                                                       5 N OCH.sub.3                                                                  F H C--H                                                                      OCH.sub.3 H H                                                                  tan 197-198                                                                    44.2 3.42                                                                      19.8                          powder  43.9 3.67 19.8                                                6 N OCH.sub.3 OCH.sub.3 H C--H Cl H H white 211-214 42.2 3.27 18.9                                                                       solid  42.0                                                                    3.23 18.4                                                                       7 N OCH.sub.3                                                                  OCH.sub.3 H                                                                   C--H F H H                                                                     white 240-241                                                                  44.2 3.42                                                                      19.8                          powder (d) 43.7 3.30 19.2                                             8 N OCH.sub.3 OCH.sub.3 H C--H CO.sub.2 CH.sub.3 H H white 189-191 45.8                                                                  3.84 17.8                                                                      powder  46.0                                                                   3.75 17.0                                                                       9 N OCH.sub.3                                                                  OCH.sub.3 H                                                                   C--H CF.sub.3                                                                  H H white                                                                      189-191 39.9                                                                   3.09 17.9                                                                      powder  43.3                                                                   3.22 16.5                                                                       10 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  H H tan                                                                       231-233 46.0                                                                   4.14 19.2                                                                      powder  46.2                                                                   4.00 19.0                                                                       11 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H CH.sub.3                                                                  H H white                                                                      188-191 48.1                                                                   4.33 20.1                                                                      powder  49.0                                                                   4.28 19.3                                                                       12 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCF.sub.3                                                                  H H white                                                                     179-181 40.1                                                                   2.88 16.7                                                                      powder  39.8                                                                   2.65 16.7                                                                       13 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OC.sub.2                                                                  H.sub.5 H H                                                                    white 224-226                                                                  47.5 4.52                                                                      18.5                          powder  47.1 4.67 18.5                                                14 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.3 H.sub.7 (n) H H tan 222-224                                                                     48.9 4.87                                                                      17.8                          powder  48.8 4.93 17.6                                                15 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.3 H.sub.7 (i) H H tan 172-174                                                                     48.9 4.87                                                                      17.8                          powder  48.9 5.09 17.6                                                16 N OCH.sub.3 OCH.sub.3 H C--H OCF.sub.2 CF.sub.2 H H H white 155-157                                                                   39.9 2.90                                                                      15.5                          powder  39.8 2.73 15.2                                                17 N OCH.sub.3 OCH.sub.3 H C--H SCH.sub.3 H H white 213-215 44.1 3.96                                                                    18.4                          powder  43.8 4.17 18.1                                                18 N OCH.sub.3 I H C--H OCH.sub.3 H H white 219-220 33.9 2.62 15.2                                                                       powder (d)                                                                     33.9 2.71                                                                      14.6                 19 N OCH.sub.3 Br H C--H OCH.sub.3 H H white 217-219 37.7 2.92 16.9                                                                      powder (d)                                                                     37.8 2.91                                                                      17.0                 20 N OCH.sub.3 H H C--H Cl Cl H tan 225-226                                             powder                                                                21 N OCH.sub.3 F H C--H Cl Cl H tan 211-212 36.7 2.06 17.9                              powder (d) 34.8 2.08 17.2                                             22 N OCH.sub.3 F H C--H OCH.sub.3 CF.sub.3 H tan 220-223 39.9 2.63 16.6                 powder  40.3 2.95 17.0                                                23 N OCH.sub.3 OCH.sub.3 H C--H Cl Cl H tan 219-221 38.6 2.74 17.3                                                                       powder (d)                                                                     38.6 2.81                                                                      17.4                 24 N OCH.sub.3 OCH.sub.3 H C--H Cl CH.sub.3 -- H white 221-223 43.8                                                                      3.68 18.3                                                                      powder (d)                                                                     43.9 3.75                                                                      18.0                 25 N OCH.sub.3 OCH.sub.3 H C--H F F H white 214-215 42.1 2.99 18.9                                                                       powder (d)                                                                     42.2 3.08                                                                      18.6                 26 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 Cl H white 223-225 42.1 3.53                                                                   17.5                          powder  42.0 3.18 17.5                                                27 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 F H white 239-240 43.9 3.68                                                                    18.3                          solid (d) 43.4 4.05 16.4                                              28 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CF.sub.3 H white 238-240 41.6                                                                  3.26 16.2                                                                      powder (d)                                                                     41.5 3.20                                                                      16.3                 29 N OCH.sub.3 OC.sub.2 H.sub.5 H C--H Cl Cl H white 217-218 40.2 3.13                                                                   16.7                          powder  40.1 3.13 16.8                                                30 N OCH.sub.3 I H C--H Cl Cl H tan 210-212 28.8 1.61 14.0                              powder (d) 28.8 1.51 13.9                                             31 N OCH.sub.3 Br H C--H Cl Cl H white 224-225 31.8 1.78 15.5                           powder (d) 32.0 1.74 15.3                                             32 N OCH.sub.3 CH.sub.3 H C--H Cl Cl H white 218-220 40.2 2.86 18.0                                                                      powder  40.0                                                                   3.22 16.3                                                                       33 N                                                                          OCH.sub.3 Cl                                                                   H C--H Cl Cl                                                                   H white                                                                        214-216 35.3                                                                   1.97 17.1                                                                      powder (d)                                                                     35.3 1.93                                                                      16.8                 34 N OCH.sub.3 Cl H C--H OCH.sub.3 CF.sub.3 H white 214-215 38.4 2.53                                                                    16.0                          powder  38.3 2.82 16.0                                                35 N OC.sub.2 H.sub.5 OCH.sub.3 H C--H OCH.sub.3 H H pink 237-238 47.5                                                                   4.52 18.5                                                                      powder  47.2                                                                   4.72 18.4                                                                       36 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  OCH.sub.3 H                                                                   tan 239-241                                                                    45.6 4.33                                                                      17.7                          solid  45.7 4.19 16.6                                                 37 N OCH.sub.3 Cl H C--H OCH.sub.3 OCH.sub.3 H yellow 216-218 42.1 3.53                                                                  17.5                          solid  42.2 3.62 17.1                                                 38 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 SCH.sub.3 H tan 232-234 43.8                                                                   4.16 17.0                                                                      solid  43.0                                                                    4.11 16.4                                                                       39 N                                                                          OCH.sub.3 Br                                                                   H C--H                                                                         OCH.sub.3                                                                      CF.sub.3 H                                                                     white 231-233                                                                  34.9 14.5                                                                      2.30                          powder (d) 34.6 14.3 2.17                                             40 N OCH.sub.3 OCH.sub.3 H C--H Cl CF.sub.3 H tan 228-230 38.4 2.53                                                                      16.0                          solid  38.5 2.51 15.7                                                 41 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CH.sub.3 H purple 235-237                                                                      47.5 4.52                                                                      18.5                          solid  47.1 5.03 18.4                                                 42 N OCH.sub.3 Cl H C--H OCH.sub.2 CH.sub.2 F CF.sub.3 H white 208-210                                                                   38.5 2.15                                                                      15.0                          powder  38.6 2.36 14.8                                                43 N OCH.sub.3 Cl H C--H OC.sub.3 H.sub.7 (i) CF.sub.3 H tan 210-213                                                                     41.3 3.25                                                                      15.0                          powder (d) 41.1 3.57 14.7                                             44 N OCH.sub.3 Cl H C--H OC.sub.2 H.sub.5 CF.sub.3 H white 212-213 39.9                                                                  2.90 15.5                                                                      powder  39.9                                                                   2.88 15.4                                                                       45 N                                                                          OCH.sub.3 Cl                                                                   H C--H                                                                         OC.sub.3                                                                       H.sub.7 (n)                                                                    CF.sub.3 H                                                                     yellow                                                                         182-184 41.3                                                                   3.25 15.0                                                                      powder  40.7                                                                   3.25 14.8                                                                       46 N                                                                          OCH.sub.3 Cl                                                                   H C--H                                                                         OCH.sub.2                                                                      CF.sub.3                                                                       CF.sub.3 H                                                                     tan 202-203                                                                    35.6 1.99                                                                      13.9                          powder  35.7 1.94 13.1                                                47 N OCH.sub.3 OCH.sub.3 H C--H F CF.sub.3 H tan 201-203 39.9 2.63 16.6                 solid  39.8 2.46 16.3                                                 48 N OCH.sub.3 OCH.sub.3 H C--H SCH.sub.3 CF.sub.3 H white 127-129 40.1                                                                  3.14 15.6                                                                      solid  40.1                                                                    3.11 15.2                                                                       49 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H Cl F H                                                                    gray 111-113                                                                   40.3 2.86                                                                      18.1                          solid  40.1 2.96 17.9                                                 50 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OC.sub.2 H.sub.5 H pink                                                                        233-234 46.9                                                                   4.68 17.1                                                                      solid (d)                                                                      46.5 4.87                                                                      15.9                 51 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 NO.sub.2 H tan 225-228 41.0                                                                    3.33 20.5                                                                      solid (d)                                                                      38.8 3.60                                                                      19.1                 52 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.2 H.sub.5 CF.sub.3 H white                                                                        232-234 43.0                                                                   3.60 15.7                                                                      powder (d)                                                                     42.9 3.51                                                                      15.7                 53 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H white                                                                      215-217 45.4                                                                   4.05 16.5                                                                      needles  44.7                                                                  3.96 16.2                                                                       54 N                                                                          OCH.sub.3 F H                                                                  C--H OCH.sub.3                                                                  OCH.sub.3 H                                                                   tan 219-220                                                                    43.9 3.68                                                                      18.3                          solid  44.1 3.92 18.0                                                 55 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 Br H tan 226-228 37.9 3.18                                                                     15.8                          solid  37.8 3.39 15.8                                                 56 N OCH.sub.3 Cl H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H tan 220-222 42.1                                                                  3.30 16.4                                                                      solid  42.1                                                                    3.28 15.9                                                                       57 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  CO.sub.2                                                                      C.sub.3                                                                        H.sub.7 H tan                                                                  228-230 47.9                                                                   4.69 15.5                                                                              (i)                                                                    solid  47.9                                                                    4.89 15.8                                                                       58 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  CO.sub.2                                                                      C.sub.2                                                                        H.sub.5 H                                                                      white 215-217                                                                  46.7 4.38                                                                      16.0                          solid  46.2 3.70 14.4                                                 59 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H                                                                      white 211-213                                                                  48.2 5.00                                                                      16.5                          solid (d) 48.2 4.87 16.7                                              60 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OC.sub.3 H.sub.7 (n) H white                                                                   197-199 48.1                                                                   5.22 16.5                                                                      solid (d)                                                                      48.6 4.94                                                                      16.1                 61 N OCH.sub.3 OCH.sub.3 H C--H CF.sub.3 CF.sub.3 H brown 204-206 38.2                                                                   2.35 14.9                                                                      solid (d)                                                                      38.2 2.03                                                                      14.7                 62 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.2 H.sub.5 CO.sub.2 CH.sub.3 H                                                                     white 200-202                 solid (d)                                                             63 N OCH.sub.3 OC.sub.2 H.sub.5 H C--H OCH.sub.3 OCH.sub.3 H white                                                                       219-221 46.9                                                                   4.68 17.1                                                                      solid  47.0                                                                    4.65 17.1                                                                       64 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H Cl                                                                        CO.sub.2                                                                       CH.sub.3 H                                                                     tan >270 42.1                                                                  3.30 16.4                                                                      powder  42.2                                                                   3.20 16.2                                                                       65 N                                                                          OCH.sub.3 I H                                                                  C--H OCH.sub.3                                                                  OCH.sub.3 H                                                                   tan 230-232                                                                    34.2 2.87                                                                      14.3                          powder (d) 34.6 2.92 14.2                                             66 N OCH.sub.3 H H C--H OCH.sub.3 OCH.sub.3 H tan 234-236 46.0 4.14                                                                      19.2                          solid  46.0 4.10 19.2                                                 67 N OCH.sub.3 OC.sub.2 H.sub.5 H C--H OCH.sub.3 CF.sub.3 H white                                                                        222-224 43.0                                                                   3.60 15.7                                                                      solid  42.4                                                                    3.60 15.1                                                                       68 N                                                                          OCH.sub.3                                                                      CH.sub.3 H                                                                     C--H OCH.sub.3                                                                  OCH.sub.3 H                                                                   tan 224-227                                                                    47.5 4.52                                                                      18.5                          solid  47.0 4.87 16.4                                                 69 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 SO.sub.2 CH.sub.3 H white                                                                      267-269 40.6                                                                   3.86 15.8                                                                      solid  41.0                                                                    3.90 15.5                                                                       70 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OC.sub.3                                                                  H.sub.7 (i)                                                                    OC.sub.3                                                                       H.sub.7 (i) H                                                                  off-wht                                                                        193-195 50.6                                                                   5.58 15.5                                                                      solid (d)                                                                      50.7 5.48                                                                      15.4                 71 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.3 H.sub.7 (n) OC.sub.3 H.sub.7                                                                    (n) H peach                                                                    158-159 50.6                                                                   5.58 15.5                                                                      solid (d)                                                                      50.3 5.51                                                                      15.5                 72 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CH.sub.2 OCH.sub.3 H tan                                                                       211-213 46.9                                                                   4.68 17.1                                                                      solid  46.8                                                                    4.68 16.9                                                                       73 N                                                                          OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H CO.sub.2                                                                  CH.sub.3                                                                       CH.sub.3 H                                                                     white 188-190                                                                  47.2 4.21                                                                      17.2                          solid  47.2 3.95 17.1                                                 74 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OC.sub.3 H.sub.7 (i) H white                                                                   204-205 48.2                                                                   5.00 16.5                                                                      solid  47.7                                                                    5.01 16.3                                                                       75 N                                                                          OCH.sub.3 I H                                                                  C--H OCH.sub.3                                                                  CF.sub.3 H                                                                    tan 235-236                                                                    31.8 2.10                                                                      13.2                          powder (d) 31.6 2.06 12.4                                             76 N OCH.sub.3 I H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H white 215-217                                                                      solid (d)                                                                       77 N                                                                          OCH.sub.3 Br                                                                   H C--H                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    white 229-231                                                                  37.9 3.18                                                                      15.8                          solid (d) 37.8 3.38 15.5                                              78 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 OCH.sub.3 OCH.sub.2 OCH.sub.3                                                                  H tan 148-150                                                                  44.8 4.65                                                                      15.4                          solid (d) 44.3 4.58 15.0                                              79 N OCH.sub.3 OCH.sub.3 H C--H F CO.sub.2 CH.sub.3 H white 209-211                                                                      43.8 3.43                                                                      17.0                          solid  43.9 3.43 16.9                                                 80 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OCF.sub.3 H white 213-215                                                                      40.1 3.14                                                                      15.6                          solid (d) 39.9 3.54 15.6                                              81 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OCH.sub.2 OCH.sub.3 H white                                                                    201-203 45.2                                                                   4.50 16.5                                                                      solid (d)                                                                      45.3 4.49                                                                      16.0                 82 N OCH.sub.3 Cl H C--H OCH.sub.3 OCH.sub.2 OCH.sub.3 H tan 152-155                                                                     41.9 3.75                                                                      16.3                          solid (d) 41.7 3.80 15.7                                              83 N OCH.sub.3 Cl COCH.sub.3 C--H OCH.sub.3 CF.sub.3 H white 224-225                                                                     40.1 2.73                                                                      14.6                          powder  40.1 2.83 14.5                                                84 N OCH.sub.3 Cl SO.sub.2 CH.sub.3 C--H OCH.sub.3 CF.sub.3 H white                                                                      241-242 34.9                                                                   2.54 13.6                                                                      powder (d)                                                                     35.4 2.74                                                                      12.9                 85 N OCH.sub.3 Cl CO.sub.2 C.sub.2 H.sub.5 C--H OCH.sub.3 CF.sub.3 H                                                                     white 230-232                                                                  40.1 2.97                                                                      13.7                          powder (d) 39.3 2.99 13.1                                             86 C--CH.sub.3 H OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H white 274-276                                                                    50.8 4.79                                                                      14.8                          solid (d) 50.3 4.90 14.9                                              87 C--H H OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H white 279-281 49.5                                                                      4.43 15.4                                                                      solid (d)                                                                      49.4 4.42                                                                      15.3                 88 C--H H OCH.sub.3 H C--H OCH.sub.3 CF.sub.3 H lt brn 257-259 44.8                                                                      3.26 13.9                                                                      solid (d)                                                                      44.5 3.27                                                                      14.0                 89 C--CH.sub.3 H OCH.sub.3 H C--H OCH.sub.3 CF.sub.3 H off-wht 261-263                                                                   46.2 3.63                                                                      13.5                          solid (d) 46.3 3.57 13.5                                              90 C--H H OCH.sub.3 H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H white 278-280                                                                   49.0 4.11                                                                      14.3                          solid (d) 48.8 4.06 14.4                                              91 C--CH.sub.3 H OCH.sub.3 H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H white                                                                    255-257 50.2                                                                   4.46 13.8                                                                      solid (d)                                                                      50.2 4.37                                                                      13.6                 92 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H purple 233-235                                                                  48.7 4.60                                                                      14.2                          solid (d) 48.8 4.57 14.2                                              93 C--H OCH.sub.3 Cl H C--H OCH.sub.3 OCH.sub.3 H off-wht 248-249 45.2                                                                   3.79 14.1                                                                      solid (d)                                                                      44.3 3.58                                                                      13.7                 94 C--H Cl OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H white 252-254 45.2                                                                     3.79 14.1                                                                      solid (d)                                                                      45.2 3.80                                                                      14.0                 95 C--H Cl OCH.sub.3 H C--H OCH.sub.3 CF.sub.3 H white 263-264 41.3                                                                      2.77 12.8                                                                      solid (d)                                                                      41.1 2.81                                                                      13.0                 96 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CF.sub.3 H off-wht 256-258                                                                  44.5 3.50                                                                      13.0                          solid (d) 44.5 3.45 12.9                                              97 C--H Cl OCH.sub.3 H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H white 218-219                                                                  45.0 3.54                                                                      13.1                          solid (d) 44.9 3.39 12.8                                              98 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H                                                                         off-wht                                                                        274-276 48.3                                                                   4.30 13.3                                                                      solid (d)                                                                      48.6 4.26                                                                      13.1                 99 C--H OCH.sub.3 OCH.sub.3 H C--H Cl Cl H lt tan 235-236                               powder (d)                                                            100 C--H OCH.sub.3 Cl H C--H Cl Cl H gray >270 38.3 2.23 13.4                           solid  3737 1.99 14.6                                                 101 C--H OCH.sub.3 H H C--H Cl Cl H purple 242-244 41.8 2.70 15.0                                                                        solid (d)                                                                      41.5 2.58                                                                      14.7                 102 C--H H OCH.sub.3 H C--H Cl Cl H white 278-280 41.8 2.70 15.0                                                                         solid (d)                                                                      41.9 2.77                                                                      15.2                 103 C--CF.sub.3 H OCH.sub.3 H C--H Cl Cl H white 247-248 38.1 2.06 7.27                 solid (d) 38.2 2.05 7.30                                              104 C--Cl H OCH.sub.3 H C--H Cl Cl H off-wht 266-269                                    solid (d)                                                             105 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H CH.sub.3 white 217-219                                                                      47.5 4.52                                                                      18.5                          powder (d) 47.7 4.61 18.3                                             106 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H Cl white 205-207 42.1 3.53                                                                  17.5                          powder  42.2 3.75 17.2                                                107 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H OCH.sub.3 white 233-235                                                                     45.6 4.33                                                                      17.7                          powder (d) 45.7 4.57 17.5                                             108 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H Br white 225-227 37.9 3.18                                                                  15.8                          powder  38.1 3.38 15.3                                                109 N OCH.sub.3 OCH.sub.3 H C--H Cl H Cl white 219-221 38.6 2.74 17.3                                                                    powder (d)                                                                     38.6 2.85                                                                      16.6                 110 N OCH.sub.3 OCH.sub.3 H C--H CH.sub.3 H F white 184-186 45.8 3.84                                                                    19.1                          powder (d) 46.0 3.92 18.8                                             111 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.2 H.sub.5 H CH.sub.3 white                                                                       197-200 48.9                                                                   4.87 17.8                                                                      powder  50.8                                                                   5.65 17.6                                                                       112 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  H C.sub.2                                                                     H.sub.5 white                                                                  200-202 48.9                                                                   4.87 17.8                                                                      powder  48.7                                                                   4.81 17.9                                                                       113 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  H C.sub.3                                                                     H.sub.7 white                                                                  199-201 50.1                                                                   5.20 17.2                                                                               (i)                                                                   powder  50.0                                                                   5.69 17.4                                                                       114 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OC.sub.2                                                                  H.sub.5 H F                                                                    white 217-219                                                                  45.3 4.06                                                                      17.6                          powder  43.7 4.08 16.8                                                115 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H CF.sub.3 white 215-216                                                                      41.6 3.26                                                                      16.2                          powder  41.3 3.51 16.0                                                116 N OCH.sub.3 OC.sub.2 H.sub.5 H C--H OCH.sub.3 H CH.sub.3 white                                                                       211-213 48.9                                                                   4.87 17.8                                                                      powder  49.1                                                                   4.91 18.0                                                                       117 N                                                                         OCH.sub.3 Br                                                                   H C--H                                                                         OCH.sub.3 H                                                                    Cl pink                                                                        204-205 34.8                                                                   2.47 15.6                                                                      solid  36.4                                                                    2.95 15.6                                                                       118 N                                                                         OCH.sub.3 Br                                                                   H C--H                                                                         OCH.sub.3 H F                                                                  white 221-223                                                                  36.1 2.57                                                                      16.2                          powder  36.1 2.64 16.0                                                119 N OCH.sub.3 I H C--H OCH.sub.3 H Cl pink 223-225 31.5 2.24 14.1                                                                      powder  32.8                                                                   2.45 13.1                                                                       120 N                                                                         OCH.sub.3 Cl                                                                   H C--H                                                                         OCH.sub.3 H                                                                    Cl white                                                                       203-205 3836                                                                   2.74 17.3                                                                      powder  3838                                                                   2.85 16.7                                                                       121 N                                                                         OCH.sub.3 Cl                                                                   H C--H                                                                         OCH.sub.3 H F                                                                  white 217-219                                                                  40.3 2.86                                                                      18.1                          powder  39.7 2.54 17.9                                                122 N OCH.sub.3 Cl H C--H OCH.sub.3 H CH.sub.3 white 195-196 43.8 3.68                                                                   18.3                          powder  43.0 4.61 18.0                                                123 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H F pink 205-207 43.9 3.68                                                                    18.3                          powder (d) 42.8 3.57 16.8                                             124 N OCH.sub.3 OCH.sub.3 H C--H SCH.sub.3 H CH.sub.3 tan 217-219 45.6                                                                   4.33 17.7                                                                      powder  46.0                                                                   5.12 17.8                                                                       125 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H SCH.sub.3                                                                  H Cl white                                                                    216-218 40.4                                                                   3.39 16.8                                                                      powder  40.5                                                                   3.39 16.7                                                                       126 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H CH.sub.3                                                                  H CH.sub.3                                                                     white 218-220                                                                  49.6 4.72                                                                      19.3                          powder  49.6 4.65 19.0                                                127 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 CH.sub.2 F H CH.sub.3 white                                                                   117-119 46.7                                                                   4.41 17.0                                                                      powder (d)                                                                     44.9 4.72                                                                      15.9                 128 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 CF.sub.3 H CH.sub.3 white                                                                     202-204 43.0                                                                   3.60 15.7                                                                      powder  43.0                                                                   3.86 15.5                                                                       129 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OC.sub.2                                                                  H.sub.5 H Cl                                                                   white 233-234                                                                  43.5 3.90                                                                      16.9                          powder (d) 43.5 4.51 16.5                                             130 N OCH.sub.3 OCH.sub.3 H C--H CO.sub.2 CH.sub.3 H F white 196-198                                                                     43.8 3.43                                                                      17.0                          solid  43.9 3.54 17.0                                                 131 N OCH.sub.3 I H C--H OCH.sub.3 H CH.sub.3 white 230-232 35.4 2.97                                                                    14.7                          solid (d) 35.6 3.06 14.3                                              132 N OCH.sub.3 OCH.sub.3 H C--H CO.sub.2 CH.sub.3 H CH.sub.3 tan                                                                        193-195 47.2                                                                   4.21 17.2                                                                      solid (d)                                                                      47.2 4.35                                                                      17.2                 133 N OCH.sub.3 CCH.sub.3 H C--H OCH.sub.2 OCH.sub.3 H CH.sub.3 tan                                                                      163-165 47.0                                                                   4.68 17.1                                                                      solid (d)                                                                      46.7 4.51                                                                      16.2                 134 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 Cl white 233-234                                                                    41.9 3.75                                                                      16.3                          powder  41.7 3.91 16.1                                                135 N OCH.sub.3 OCH.sub.3 H C--H Cl CH.sub.3 Cl white 180-182 40.2 3.13                                                                  16.7                          powder  38.3 3.50 15.4                                                136 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 Cl Cl white 227-228 38.7                                                                      3.02 16.1                                                                      powder  38.6                                                                   3.25 15.9                                                                       137 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  CO.sub.2                                                                      CH.sub.3 Cl                                                                    white 236-238                                                                  42.0 3.52                                                                      15.3                          powder (d) 42.0 3.52 15.0                                             138 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 CH.sub.3 tan                                                                        228-230 46.9                                                                   4.68 17.1                                                                      solid (d)                                                                      47.0 4.60                                                                      17.1                 139 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 F CH.sub.3 tan 205-208 45.3                                                                   4.06 17.6                                                                      solid (d)                                                                      45.4 4.07                                                                      17.3                 140 N OCH.sub.3 Cl H C--H OCH.sub.3 OCH.sub.3 CH.sub.3 tan 223-225 43.5                                                                  3.90 16.9                                                                      solid (d)                                                                      43.3 3.90                                                                      16.6                 141 N OCH.sub.3 OCH.sub.3 H N OCH.sub.3 H H tan 242-244 42.6 3.85 22.9                                                                   powder (d)                                                                     42.6 3.82                                                                      21.6                 142 N OCH.sub.3 OCH.sub.3 H N OCH.sub.3 CF.sub.3 H white 214-216 38.7                                                                    3.02 19.4                                                                      powder  38.5                                                                   3.15 19.4                                                                       143 C--H H                                                                    OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  H H lt tan                                                                    249-250 50.3                                                                   4.22 16.8                                                                      powder (d)                                                                     50.4 4.10                                                                      16.8                 144 C--H OCH.sub.3 H H C--H OCH.sub.3 H H off-wht 249-250 50.3 4.22                                                                      16.8                          powder (d) 50.4 3.93 16.8                                             145 C--H OC.sub.2 H.sub.5 H H C--H OCH.sub.3 H H lt tan 250-251 51.7                                                                     4.63 16.1                                                                      powder (d)                                                                     51.8 4.65                                                                      16.2                 146 N OCH.sub.3 Cl H C--H OCH.sub.3 F CH.sub.3 tan 196-198 41.9 3.26                                                                     17.4                          solid  41.6 3.39 17.6                                                 147 N OCH.sub.3 OCH.sub.3 H C--H F OCH.sub.3 CH.sub.3 lt red 165-168                                                                     45.3 4.06                                                                      17.6                          solid  45.3 4.06 17.6                                                 148 N OCH.sub.3 Cl H C--H F OCH.sub.3 CH.sub.3 tan 176-178 41.9 3.26                                                                     17.4                          solid  41.5 3.27 17.3                                                 149 N OCH.sub.3 OCH.sub.3 H C--H CF.sub.3 OCH.sub.3 CH.sub.3 tan                                                                         183-185                                                                        solid                                                                           150 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  OCH.sub.2                                                                     CH.sub.2 -- H                                                                  white 173-175                                                                  46.5 4.82                                                                      15.9                        OCH.sub.3  solid  46.5 4.87 15.9                                        151 N OCH.sub.3 Cl H C--H OCH.sub.3 CH.sub.2 OC.sub.3 H.sub.7 H white                                                                    224-226 46.2                                                                   4.56 15.9                                                                              (i)                                                                    solid  45.9                                                                    4.46 15.5                                                                       152 N                                                                         OCH.sub.3                                                                      SCH.sub.3 H                                                                    C--H Cl Cl H                                                                   tan 207-209                                                                    37.2 2.64                                                                      16.7                          solid  37.2 2.56 16.5                                                 153 N OCH.sub.3 SCH.sub.3 H C--H OCH.sub.3 CF.sub.3 H tan 215-217 40.1                                                                   3.14 15.5                                                                      solid  40.0                                                                    3.18 15.4                                                                       154 N                                                                         OCH.sub.3 Cl                                                                   H C--H                                                                         OCF.sub.3 H                                                                    CH.sub.3 tan                                                                   182-184 38.4                                                                   2.53 15.0                                                                      solid  38.1                                                                    2.39 15.6                                                                       155 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H N                                                                  OCH.sub.3 Cl                                                                   H white                                                                        227-228 39.0                                                                   3.27 21.0                                                                      powder  38.7                                                                   3.14 20.9                                                                       156 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H N                                                                  OCH.sub.3                                                                      OCH.sub.3 H                                                                    tan 223-225                                                                    42.4 4.07                                                                      21.2                          powder  41.8 3.96 20.5                                                157 C--H OC.sub.2 H.sub.5 OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H white                                                                   241-243 50.0                                                                   4.94 13.7                                                                      solid (d)                                                                      49.9 4.80                                                                      13.6                 158 C--H Cl OCH.sub.3 H C--H OCH.sub.3 Cl H white 264-266 41.7 3.00                                                                      13.9                          solid (d) 41.7 2.97 13.9                                              159 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 Cl H white 246-248 45.2                                                                    3.79 14.1                                                                      solid (d)                                                                      45.3 3.69                                                                      14.0                 160 C--H Cl OCH.sub.3 H C--H OCH.sub.3 H CH.sub.3 white 245-247 47.1                                                                     3.95 14.6                                                                      solid (d)                                                                      47.0 3.93                                                                      14.4                 161 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H CH.sub.3 white 258-260                                                                   50.8 4.79                                                                      14.8                          solid (d) 49.9 4.48 14.2                                              162 C--H Cl OCH.sub.3 H C--H OCH.sub.3 H Cl white 207-211 41.7 3.00                                                                      13.9                          solid (d) 41.8 2.90 13.7                                              163 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H Cl white 228-230 45.2                                                                    3.79 14.1                                                                      solid (d)                                                                      45.2 3.84                                                                      14.0                 164 C--H Br OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H white 243-245 40.6                                                                    3.41 12.6                                                                      solid (d)                                                                      40.6 3.38                                                                      12.5                 165 C--Cl H OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H white 268-270 45.2                                                                    3.79 14.1                                                                      solid (d)                                                                      45.1 3.82                                                                      14.0                 166 N OCH.sub.3 Cl H C--H OCH.sub.3 Cl Cl tan 217-219 35.6 2.30 16.0                                                                     powder  35.5                                                                   2.44 15.6                                                                       167 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  CH.sub.2 F                                                                    CF.sub.3 H                                                                     white 233-235                                                                  41.3 3.25                                                                      15.1                          powder  41.4 3.09 14.9                                                168 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 OCH.sub.3 CF.sub.3 H white                                                                    181-183 41.5                                                                   3.48 15.1                                                                      solid (d)                                                                      41.6 3.42                                                                      15.0                 169 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CO.sub.2 CH.sub.3 H white                                                                  224-226 44.7                                                                   3.75 12.3                                                                      solid  44.5                                                                    3.68 12.3                                                                       170 N                                                                         OCH.sub.3 Cl                                                                   H C--H                                                                         CO.sub.2                                                                       CH.sub.3 H                                                                     CH.sub.3                                                                       off-wht                                                                        174-176 43.8                                                                   3.43 17.0                                                                      solid  43.5                                                                    3.33 16.8                                                                       171 N                                                                         OCH.sub.3 Cl                                                                   H C--H                                                                         OCH.sub.2                                                                      OCH.sub.3 H                                                                    CH.sub.3                                                                       off-wht                                                                        199-201 43.5                                                                   3.90 16.9                                                                      solid  43.2                                                                    3.87 16.7                                                                       172 C--H                                                                      OCH.sub.3                                                                      OCH.sub.3 H N                                                                  OCH.sub.3                                                                      CF.sub.3 H                                                                     white 226-227                                                                  41.6 3.26                                                                      16.2                          solid  41.7 3.24 15.9                                                 173 N OCH.sub.3 Cl H N OCH.sub.3 CF.sub.3 H 238-240 white 35.7 2.07                                                                      19.2                           powder 35.9 2.22 19.2                                                174 N OCH.sub.3 OCH.sub.3 H N Cl OCH.sub.3 H 228-229 white 39.0 3.26                                                                     21.0                          (d) powder 38.8 3.13 21.7                                             175 C--H OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CO.sub.2 C.sub.2 H.sub.5                                                                   H tan 204-206                                                                  49.5 4.62                                                                      12.8                          solid (d) 49.3 4.53 12.6                                              176 C--H OCH.sub.3 OCH.sub.3 H C--H OC.sub.4 H.sub.9 (i) OC.sub.4                                                                        H.sub.9 (i) H                                                                  tan 145-147                                                                    52.6 6.10                                                                      14.6                          solid  52.5 6.08 14.4                                                 177 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.3 H.sub.7 (n) CF.sub.3 H white                                                                   202-204 44.3                                                                   3.93 15.2                                                                      solid  44.1                                                                    3.81 15.0                                                                       178 N                                                                         OCH.sub.3 Cl                                                                   H C--H                                                                         OCH.sub.3 Cl                                                                   H tan >250                                                                     powder                                                                          179 N                                                                         OCH.sub.3 Cl                                                                   H C--H                                                                         OC.sub.2                                                                       H.sub.5 H                                                                      CH.sub.3 tan                                                                   214-216 45.3                                                                   4.05 17.6                                                                      powder  45.0                                                                   3.86 17.3                                                                       180 C--H Br                                                                   OCH.sub.3 H                                                                    C--H OC.sub.2                                                                  H.sub.5                                                                        OC.sub.2                                                                       H.sub.5 H                                                                      white 244-246                                                                  43.3 4.06                                                                      11.9                          solid  43.3 3.90 11.9                                                 181 C--OCH.sub.3 H OCH.sub.3 H C--H OCH.sub.3 OCH.sub.3 H white 274-276                                                                  48.7 4.60                                                                      14.2                          powder  48.7 4.50 14.1                                                182 N OCH.sub.3 Cl H C--H OC.sub.3 H.sub.7 (i) OC.sub.3 H.sub.7 (i) H                                                                    tan 174-176                                                                    47.4 4.86                                                                      15.4                          solid  47.5 4.90 15.3                                                 183 C--H OCH.sub.3 OCH.sub.3 H C--H OC.sub.2 H.sub.5 OC.sub.2 H.sub.5 H                                                                  purple                                                                         243-245 51.2                                                                   5.25 13.3                                                                      solid  50.2                                                                    5.11 12.9                                                                       184 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  CH.sub.2 --                                                                   CF.sub.3 H                                                                     off-wht                                                                        233-235 42.8                                                                   3.80 14.7                                                                      OCH.sub.3                                                                      solid  42.7                                                                    3.69 14.7                                                                       185 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  CF.sub.3                                                                      CF.sub.3 H                                                                     white 211-213                                                                  38.3 2.61                                                                      14.0                          solid  38.3 2.59 13.9                                                 186 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 CN CF.sub.3 H off-wht                                                                         211-213 41.9                                                                   2.86 18.3                                                                      solid  41.6                                                                    2.88 17.6                                                                       187 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH--                                                                     CF.sub.3 H                                                                     white 229-231                                                                  40.1 3.24                                                                      14.1                       (CH.sub.2 F).sub.2   solid  41.0 3.12 14.0                               188 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 -- CF.sub.3 H white 152-157                                                                   42.8 3.80                                                                      14.7                       OC.sub.2 H.sub.5   solid  42.6 3.70 13.4                                 189 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 -- CF.sub.3 H white 209-211                                                                   37.0 2.38                                                                      12.7                       CF.sub.2 CF.sub.3   solid  36.8 2.23 12.5                                190 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 CHF.sub.2 CF.sub.3 H tan                                                                      223-224 39.8                                                                   2.92 14.5                                                                      solid  39.5                                                                    2.74 14.3                                                                       191 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  CH.sub.2 F H                                                                  F white                                                                        195-199                                                                        solid                                                                           192 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  OCH.sub.3 H                                                                   F off-wht                                                                      155-165                                                                        solid                                                                           193 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  OCH.sub.3 H                                                                   Cl off-wht                                                                     185-190 41.9                                                                   3.72 16.3                                                                      solid  41.9                                                                    3.70 15.9                                                                       194 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OC.sub.3                                                                  H.sub.7 (i)                                                                    CF.sub.3 H                                                                     tan 232-234                                                                    44.3 3.93                                                                      15.2                          solid  44.2 3.93 15.0                                                 195 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.4 H.sub.9 (n) CF.sub.3 H white                                                                   185-187 45.5                                                                   4.24 14.7                                                                      solid  45.2                                                                    4.27 14.6                                                                       196 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  OCH.sub.3 H                                                                   H tan 167-169                                                                  45.6 4.33                                                                      17.7                          solid  45.2 4.20 16.9                                                 197 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 CH.sub.2 F H H white 203-205                                                                  45.3 4.06                                                                      17.6                          solid  44.4 3.93 17.2                                                 198 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 CF.sub.3 H H white 209-211                                                                    41.6 3.26                                                                      16.2                          solid  41.6 3.28 16.0                                                 199 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.4 H.sub.9 (i) CF.sub.3 H tan                                                                     217-219 45.4                                                                   4.24 14.7                                                                      solid  45.2                                                                    4.17 14.5          200                                                                               N    OCH.sub.3                                                                          OCH.sub.3                                                                          H     C--H                                                                              CF.sub.3                                                                               OCH.sub.2 O                                                                              white                                                                               193-195                                                                             40.3                                                                               2.70                                                                              15.7                         solid  40.2 2.74 15.4                                                201                                                                               N    OCH.sub.3                                                                          OCH.sub.3                                                                          H     C--H                                                                              OCH--   H     H   white                                                                               203-204                                                                             44.8                                                                               3.99                                                                              16.3                       (CH.sub.2 F).sub.2   solid  44.9 3.91 16.2                               202 N OCH.sub.3 OCH.sub.3 H C--H OC.sub.4 H.sub.9 (s) CF.sub.3 H tan                                                                     186-188 45.5                                                                   4.24 14.7                                                                      solid  45.4                                                                    4.20 14.7                                                                       203 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  -- CF.sub.3                                                                   H off-wht                                                                      230-231 39.9                                                                   3.14 14.5                                                                      CH.sub.2 Cl                                                                    solid  39.8                                                                    3.07 14.4                                                                       204 N                                                                         OCH.sub.3                                                                      CH.sub.3 H                                                                     C--H OCH.sub.3                                                                  CF.sub.3 H                                                                    white 135-137                                                                  43.2 3.38                                                                      16.8                          powder  43.0 3.33 16.5                                                205 N OCH.sub.3 Br H C--H OCH.sub.2 OCH.sub.3 CF.sub.3 H white 197-199                                                                   35.2 2.56                                                                      13.7                          powder  35.3 2.46 13.6                                                206 N OCH.sub.3 OC.sub.2 H.sub.5 H C--H OCH.sub.2 OCH.sub.3 CF.sub.3 H                                                                   white 175-176                                                                  41.3 3.90                                                                      15.0                          powder  42.5 3.63 14.4                                                207 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 OCH.sub.3 CF.sub.3 H white                                                                    181-183 41.5                                                                   3.48 15.1                                                                      solid (d)                                                                      41.6 3.42                                                                      15.0                 208 N OCH.sub.3 OCH.sub.3 H N OC.sub.2 H.sub.5 CF.sub.3 H off-wht                                                                        211-213 40.2                                                                   3.37 18.7                                                                      solid  40.4                                                                    3.33 18.5                                                                       209 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H N                                                                  OCH.sub.2                                                                      CH.sub.2 F                                                                     CF.sub.3 H                                                                     tan 226-228                                                                    38.6 3.03                                                                      18.0                          solid  38.5 2.88 17.9                                                 210 N OCH.sub.3 OCH.sub.3 H N OCH.sub.2 -- CF.sub.3 H white 166-168                                                                      41.7 3.28                                                                      18.3                       CH═CH.sub.2   solid  41.6 3.22 18.0                                  211 N OCH.sub.3 OCH.sub.3 H N OC.sub.3 H.sub.7 (i) CF.sub.3 H white                                                                      219-221 41.6                                                                   3.71 18.2                                                                      solid  41.6                                                                    3.66 18.1                                                                       212 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H N                                                                  OCH.sub.3 H                                                                    CH.sub.3                                                                       white 141-142                                                                  44.2 4.24                                                                      22.1                          powder  43.5 4.07 21.0                                                213 N OCH.sub.3 Br H N OCH.sub.3 CF.sub.3 H tan 235-237 32.3 2.06 17.4                                                                   powder (d)                                                                     32.3 2.06                                                                      17.2                 214 C--H Br OCH.sub.3 H N OCH.sub.3 CF.sub.3 H white 241-243 34.9 2.30                                                                   14.5                          solid  35.0 2.20 14.3                                                 215 C--H OCH.sub.3 OCH.sub.3 H C--H OC.sub.2 H.sub.5 CO.sub.2 CH.sub.3                                                                   H yellow                                                                       197-198 49.5                                                                   4.62 12.8                                                                      solid  50.0                                                                    4.83 12.2                                                                       216 N                                                                         OCH.sub.3                                                                      OCH.sub.3                                                                      SO.sub.2                                                                       CH.sub.3 C--H                                                                  OCH.sub.3                                                                      CO.sub.2                                                                       CH.sub.3 H                                                                     tan 230-231                                                                    39.3 3.91                                                                      14.3                          powder  40.3 3.76 13.3                                                217 C--H OCH.sub.3 OCH.sub.3 SO.sub.2 CH.sub.3 C--H OCH.sub.3 CO.sub.2                                                                   CH.sub.3 H                                                                     tan 248-249                                                                    powder (d)                                                                      218 N                                                                         OCH.sub.3 Cl                                                                   H C--H F                                                                       CF.sub.3 H                                                                     tan 191-193                                                                    36.7 1.89                                                                      16.5                          solid  36.7 1.80 16.3                                                 219 N OCH.sub.3 Cl H C--H OCH.sub.2 OCH.sub.3 CF.sub.3 H lt tan 161-163                                                                  38.5 2.80                                                                      15.0                          solid (d) 38.0 2.67 13.8                                              220 N OCH.sub.3 OCH.sub.3 COCH.sub.3 C--H OCH.sub.2 CH.sub.2 F CF.sub.3                                                                  H tan 217-220                                                                  42.6 3.38                                                                      15.0                          powder  42.2 3.33 13.6                                                221 N OCH.sub.3 OCH.sub.3 H C--H CO.sub.2 CH.sub.3 CF.sub.3 H                  222 N OCH.sub.3 OCH.sub.3 H C--H OCF.sub.3 CF.sub.3 H                          223 N OCH.sub.3 OCH.sub.3 H C--H Br CF.sub.3 H                                 224 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 -- CF.sub.3 H                             CH═CH.sub.2                                                          225 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 SCH.sub.3 CF.sub.3 H                                                                           226 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H CH.sub.2                                                                  OCH.sub.3                                                                      CF.sub.3 H                                                                      227 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OC.sub.3                                                                  H.sub.7 (i)                                                                    CH.sub.2                                                                       CF.sub.3 H                                                                      228 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.3                                                                  OCF.sub.2                                                                     OCH.sub.3 H                                                                     229 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H O(CH.sub.                                                                 2).sub.3 F                                                                     CF.sub.3 H                                                                      230 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  CH.sub.2 F                                                                    CO.sub.2                                                                       CH.sub.3 H                                                                      231 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCF.sub.3                                                                  OCH.sub.2                                                                     CH.sub.2 F H                                                                    232 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCF.sub.3                                                                  OCH-- H                                                                       (CH.sub.2                                                                      F).sub.2                                                                        233 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH--                                                                     CF.sub.3 H                                                                     (CH.sub.2                                                                      Cl).sub.2                                                                       234 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  -- CF.sub.3                                                                   H                          CHCl.sub.2                                                                - 235 N OCH.sub.3 OCH.sub.3 H C--H                                                                                                        CF.sub.3 H                                                                     - 236 N                                                                      OCH.sub.3                                                                      OCH.sub.3                                                                      SO.sub.2                                                                       CH.sub.3 C--H                                                                  OCH.sub.2                                                                      CH.sub.2 F                                                                     CF.sub.3 H                                                                      237 N                                                                         OCH.sub.3                                                                      OCH.sub.3                                                                      COCH.sub.3                                                                     C--H OCH.sub.2                                                                  CH.sub.2 F                                                                    CF.sub.3 H                                                                      238 N                                                                         OCH.sub.3                                                                      OCH.sub.3                                                                      CH.sub.2                                                                       CH.sub.2 --                                                                    C--H OCH.sub.2                                                                  CH.sub.2 F                                                                    CF.sub.3 H                                                                          CO.sub.2                                                                  CH.sub.3                                                                        239 N                                                                         OCH.sub.3                                                                      OCH.sub.3 H                                                                    C--H OCH.sub.2                                                                  CH.sub.2 F H                                                                  Cl                   240 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.2 CF.sub.3 H Cl                       241 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 H CH.sub.2 F                        242 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CF.sub.3 Cl                         243 N OCH.sub.3 OCH.sub.3 H C--H Cl CF.sub.3 OCH.sub.3                         244 N OCH.sub.3 OCH.sub.3 H N CF.sub.3 OCH.sub.3 H                             245 N OCH.sub.3 OCH.sub.3 H N OCH.sub.3 CO.sub.2 CH.sub.3 H                    246 N OCH.sub.3 OCH.sub.3 H N OCH.sub.3 H Cl                                   247 N OCH.sub.3 OCH.sub.3 H N OCH.sub.2 OCH.sub.3 CF.sub.3 H                   248 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 CH.sub.2 F H                        249 N OCH.sub.3 OCH.sub.3 H C--H OCH.sub.3 SCF.sub.3 H                       __________________________________________________________________________

The compounds of Formula I wherein T represents hydrogen can be prepared by the reaction of a substituted 2-amino[1,2,4]triazoloazine compound of Formula II: ##STR5## with a benzenesulfonyl chloride or pyridine-3-sulfonyl chloride compound of Formula III: ##STR6## wherein A, B, D, Q, W, X, and Z are as defined herein-above for compounds of Formula I. The reaction can be carried out by combining approximately equal molar amounts of the two compounds in a polar, aprotic solvent, such as acetonitrile, and adding pyridine and a catalytic amount (5 to 25 molar percent of the sulfonyl chloride compound) of dimethyl sulfoxide at room temperature. Additional sulfonyl chloride compound, pyridine, and dimethyl sulfoxide are added, if necessary, to complete the reaction. The reactions take from a few hours to several days to go to completion. Means to exclude moisture, such as a dry nitrogen blanket, are employed. The compounds of Formula I obtained, which are solids with low solubility in many common organic solvents and in water, can be recovered using conventional means.

The condensation reaction of sulfonyl chloride compounds of Formula III and 2-amino[1,2,4]triazoloazine compounds of Formula II can be carried out advantageously by first converting the 2-amino[1,2,4]triazoloazine compound of Formula II into an N-trialkylsilyl derivative of Formula IV: ##STR7## wherein W, X, and Z are as defined for compounds of Formula I and R" represents C₁ -C₄ alkyl. N-Trimethylsilyl and N-triethylsilyl derivatives are typical. The method is related to those disclosed in U.S. Pat. Nos. 4,910,306 and 4,666,501, but differs in that it generally requires a fluoride ion facilitator.

The conversion of a 2-amino[1,2,4]triazoloazine compound of Formula II to an N-trialkylsilyl derivative of Formula IV can be carried out by preparing a mixture of a chlorotrialkylsilane compound with sodium or potassium iodide in a solvent, such as acetonitrile, under anhydrous conditions and then adding the 2-amino[1,2,4]triazoloazine compound and a trialkylamine compound, such as triethylamine, typically at ambient temperatures and with agitation. Approximately equimolar amounts of the chlorotrialkylsilane and 2-amino[1,2,4]triazoloazine compounds are generally employed. The reaction requires from a few hours to a day depending on the specific trialkylamine and 2-amino[1,2,4]triazoloazine compounds involved. The N-trialkylsilyl derivatives prepared can be recovered by diluting the resulting mixture with a non-polar solvent, such as ether or 1,2-dichloroethane, removing the insoluble salts by filtration, and removing the volatile components by evaporation under reduced pressure. Compounds of Formula IV are unstable in the presence of water and must be kept dry.

The 2-(trialkylsilylamino)[1,2,4]triazoloazine derivatives of Formula IV obtained as described above or in other ways can be condensed, with or without further purification, with a sulfonyl chloride compound of Formula III. The condensation is typically carried out in a solvent, such as acetonitrile, in the presence of an approximately equimolar amount of a pyridine or methylpyridine base, an approximately equimolar amount of a fluoride ion facilitator, such as cesium fluoride or a tetraalkylammonium fluoride, and a catalytic amount (about 3 to about 20 percent of the sulfonyl chloride compound) of dimethyl sulfoxide. The condensation, which is typically carried out at temperatures of from about 10° C. to about 60° C. under anhydrous conditions with agitation, is generally complete in about 2 to 18 hours. The N-(triazoloazinyl)arylsulfonamide compounds of Formula I obtained can be recovered by conventional means, such as by filtration to collect the solids and extraction of the solids obtained to remove the water-soluble salts and/or soluble organic components.

N-(triazoloazinyl)arylsulfonamide compounds of Formula I wherein T represents other than hydrogen can be prepared from the corresponding compounds of Formula I wherein T represents hydrogen by acylation under reaction conditions known in the art for related sulfonamide acylation reactions. Suitable acylating agents include alkanoyl chloride compounds, such as propionyl chloride or trifluoroacetyl chloride; chloroformate ester compounds, such as 2-methoxyethyl chloroformate; carbamoyl chloride compounds, such as N',N',-diallylcarbamoyl chloride, and alkyl isocyanate compounds, such as 2-chloroethyl isocyanate.

Compounds of Formula I wherein W represents chloro can be converted into corresponding compounds of Formula I whereby W represents fluoro, bromo, iodo, O(C₁ -C₃ alkyl), or S(C₁ -C₃ alkyl) by treatment with an appropriate nucleophile using the general methods for such replacements known in the art. Chloro substituents in the 5-position (X) are generally more easily replaced than are chloro substituents in the 6-position (Y) or the 8-position (Z) and can be selectively replaced.

Many 2-amino[1,2,4]triazolo[1,5-a]pyridine compounds of Formula II (X represents C--Y) can be prepared by the reaction of appropriately substituted N-(2-pyridinyl)-N'-carboethoxythiourea compounds of the formula: ##STR8## with hydroxylamine. The reaction is typically carried out in a solvent such as ethanol and requires heating for a few hours. The hydroxylamine is typically generated by neutralization of the hydrochloride with a hindered tertiary amine, such as diisopropylethylamine, or an alkali metal alkoxide, such as sodium ethoxide. The desired compounds of Formula II can be recovered by conventional means, such as by removal of the volatile components of the reaction mixture by evaporation, and can be purified by conventional means, such as by extraction with water and/or other solvents in which they are sparingly soluble. The N-(2-pyridinyl)-N'-carboethoxythiourea compound starting materials for this method can be obtained by treatment of appropriately substituted 2-aminopyridine compounds with ethoxycarbonyl isothiocyanate. The reaction is generally carried out in an inert organic solvent at ambient temperatures. The overall method is further described in U.S. Pat. No. 5,571,775.

The substituted 2-aminopyridine compound starting materials for the method described above are known in the art or can be prepared by the methods disclosed herein or by general methods known in the art.

Compounds of Formula II wherein X represents C--Y can also be prepared from appropriately substituted 2-cyanoaminopyridine compounds by the method disclosed by B. Vercek et al. in Monatshefte fur Chemie, 114, 789-798 (1983). Additional methods of preparation of such compounds were disclosed by K. T. Potts et al. in Journal of Organic Chemistry, 31, 265-273 (1966).

Compounds of Formula I wherein X represents N (2-amino[1,2,4]triazolo[1,5-c]pyrimidine compounds) can be prepared from 4-hydrazinopyrimidine compounds of the formula: ##STR9## wherein W represents methylthio, hydrogen, or chloro and Z represents hydrogen, halogen, alkoxy, or alkylthio. The hydrazinopyrimidine compound is first treated with cyanogen bromide to produce the hydrobromide of a 3-amino-8-substituted-5-substituted[1,2,4]triazolo[4,3-c]pyrimidine compound of the formula: ##STR10## wherein W represents methylthio, hydrogen, or chloro and Z represents hydrogen, halogen, alkoxy, or alkylthio. The reaction is generally carried out in an organic solvent, such as isopropyl alcohol, at ambient temperature. The products can be recovered by conventional means, such as by adding a non-polar solvent, for example diethyl ether, and collecting the solid that forms by filtration. The above intermediates wherein W represents methylthio can then be converted into the desired compounds of Formula II wherein W represents an alkoxy group by treatment with an alkali metal alcoholate, such as sodium methylate or potassium ethylate, and ethyl acrylate in the corresponding alcohol as a solvent. The compound rearranges and the methylthio moiety is replaced by the alkoxy moiety derived from the alcohol of the medium. The reaction is generally carried out at temperatures below 25° C. The desired compounds of Formula II can be recovered by neutralizing with acetic acid and collecting the solids that form by filtration or other conventional means. Compounds of Formula II wherein X represents N and W represents hydrogen or chloro can be obtained from the corresponding [4,3-c] intermediate wherein W represents hydrogen or chloro by isomerization with a trialkylamine base. The 4-hydrazinopyrimidine compound starting materials for these methods can be prepared from the corresponding 4-chloropyrimidine compounds, which are well-known in the art, by reaction with hydrazine.

Other methods of preparation of compounds of Formula II wherein X represents N are disclosed by G. W. Miller, et al., J. Chemical Society, 1965, page 3357 and 1963, page 5642.

Compounds of Formula II wherein X represents N are a further embodiment of the invention. Thus, the invention includes 2-amino[1,2,4]triazolo[1,5-c]pyrimidine compounds of the formula: ##STR11## wherein W represents O(C₁ -C₃ alkyl), Cl, Br, F, or H and Z represents O(C₁ -C₃ alkyl), H, F, Cl, Br, I, S(C₁ -C₃ alkyl), or CH₃ optionally substituted with up to three fluorine atoms; with the proviso that at least one of W and Z represents O(C₁ -C₃ alkyl). Compounds of this type wherein one of W and Z represents methoxy and the other represents fluoro, chloro, bromo, methyl, methoxy, or ethoxy are often preferred and such compounds wherein W repesents methoxy and Z represents methoxy, fluoro, chloro, or bromo are often more preferred.

The substituted benzenesulfonyl chloride and pyridinesulfonyl chloride starting materials of Formula III can be prepared by the methods disclosed herein or by general or specific methods known in the art. Many such compounds, such as 2-methoxy-6-(trifluoromethyl)benzenesulfonyl chloride and 2-methoxy-4-(trifluoromethyl)-3-pyridinesulfonyl chloride, can be prepared by lithiation of the corresponding benzene or pyridine compound (e.g., 3-(trifluoromethyl)anisole or 2-methoxy-4-(trifluoromethyl)pyridine with butyl lithium, reaction of the phenyl or pyridinyl lithium compound obtained with dipropyl disulfide, and then chloroxidation of the resulting propylthio compound. In each of these reaction steps conditions generally known for such processes were used. Many propyl or benzylthiobenzenes and pyridines can also be prepared by alkylation of the corresponding thiophenol or 3-pyridinethiol compound using standard methods and subsequent chloroxidation. Phenyl and pyridinyl lithium compounds, such as that derived from 1,3-dimethoxybenzene can be converted directly to the corresponding desired sulfonyl chloride compounds by reaction with sulfur dioxide and sulfuryl chloride in the presence of N,N,N',N',-tetramethylethylenediamine. Other of the required sulfonyl chloride compounds, such as 2-(1,1,2,2-tetrafluoroethoxy)benzenesulfonyl chloride, can be prepared by diazotization of the corresponding aniline or 3-aminopyridine compounds in the presence of sulfur dioxide, copper chlorides, and concentrated aqueous hydrochloric acid. Benzenesulfonyl chloride compounds, such as 2-methoxy-5-methylbenzenesulfonyl chloride, can be prepared by direct chlorosulfonation of appropriate benzene compounds. 3-Alkylthiopyridine compounds having chloro substituents in the 2- and/or 4-positions can be converted to the corresponding compounds having other halo or alkoxy substituents by conventional nucleophilic displacement processes before chloroxidation to produce other pyridine-3-sulfonyl chloride compounds.

Compounds of Formula III wherein Q represents N, including substituted pyridine-3-sulfonyl chloride compounds of the formula: ##STR12## wherein A represents H, F, Cl, Br, or I, or CO₂ (C₁ -C₄ alkyl) or represents C₁ -C₃ alkyl, O(C₁ -C₄ alkyl), O(C₃ -C₄ alkenyl), O(C₃ -C₄ alkynyl), or S(C₁ -C₃ alkyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms, or represents a 2-methyl-1,3-dioxolan-2-yl moiety; B represents H, F, Cl, Br, I, NO₂, CN, CO₂ (C₁ -C₄ alkyl), NH(C₁ -C₃ alkyl), or N(C₁ -C₃ alkyl)₂ or represents O(C₁ -C₄ alkyl), O(C₃ -C₄ alkenyl), O(C₃ -C₄ alkynyl), C₁ -C₃ alkyl, S(C₁ -C₃ alkyl), SO(C₁ -C₃ alkyl), SO₂ (C₁ -C₃ alkyl), S(C₃ -C₄ alkenyl), SO(C₃ -C₄ alkenyl), SO₂ (C₃ -C₄ alkenyl), S(C₃ -C₄ alkynyl), SO(C₃ -C₄ alkynyl), or SO₂ (C₃ -C₄ alkynyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms; with the proviso that at least one of A and B represents O(C₁ -C₄ alkyl), O(C₃ -C₄ alkenyl), or O(C₃ -C₄ alkynyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, or bromo substituent or with up to the maximum possible number of fluorine atoms; with the proviso that A and B do not simultaneously represent H; and D represents H, F, Cl, Br, I, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, or CF₃ ; or B and D together represent a fragment of the formula O--CH₂ --O, optionally substituted with one or two F or CH₃, are further embodiments of the invention. Pyridine-3-sulfonyl chloride compounds of Formula III wherein A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, 1-(fluoromethyl)-2-fluoroethoxy, trifluoromethoxy, chloro, or fluoro; B represents hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethyl, methylthio, methyl, trifluoromethyl, trifluoromethoxy, fluoro, chloro, or methoxycarbonyl; and D represents hydrogen, fluoro, chloro, bromo, or methyl are typically preferred. Such compounds wherein B represents methoxy and D represents hydrogen; wherein A represents methoxy and D represents hydrogen, methyl, or chloro; or wherein B represents trifluoromethyl and D represents hydrogen are often more preferred. Compounds of Formula III wherein Q represents N and A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, or 1-(fluoromethyl)-2-fluoroethoxy; B represents hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, trifluoromethyl, or methoxycarbonyl; and D represents hydrogen or methyl are usually most preferred.

While it is possible to utilize the N-(triazoloazinyl)arylsulfonamide compounds of Formula I directly as herbicides, it is preferable to use them in mixtures containing an herbicidally effective amount of the compound along with at least one agriculturally acceptable adjuvant or carrier. Suitable adjuvants or carriers should not be phytotoxic to valuable crops, particularly at the concentrations employed in applying the compositions for selective weed control in the presence of crops, and should not react chemically with the compounds of Formula I or other composition ingredients. Such mixtures can be designed for application directly to weeds or their locus or can be concentrates or formulations which are normally diluted with additional carriers and adjuvants before application. They can be solids, such as, for example, dusts, granules, water dispersible granules, or wettable powders, or liquids, such as, for example, emulsifiable concentrates, solutions, emulsions or suspensions.

Suitable agricultural adjuvants and carriers that are useful in preparing the herbicidal mixtures of the invention are well known to those skilled in the art.

Liquid carriers that can be employed include water, toluene, xylene, petroleum naphtha, crop oil, acetone, methyl ethyl ketone, cyclohexanone, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol monomethyl ether and diethylene glycol monomethyl ether, methanol, ethanol, isopropanol, amyl alcohol, ethylene glycol, propylene glycol, glycerine, N-methyl-2-pyrrolidinone, and the like. Water is generally the carrier of choice for the dilution of concentrates.

Suitable solid carriers include talc, pyrophyllite clay, silica, attapulgus clay, kieselguhr, chalk, diatomaceous earth, lime, calcium carbonate, bentonite clay, Fuller's earth, cotton seed hulls, wheat flour, soybean flour, pumice, wood flour, walnut shell flour, lignin, and the like.

It is frequently desirable to incorporate one or more surface-active agents into the compositions of the present invention. Such surface-active agents are advantageously employed in both solid and liquid compositions, especially those designed to be diluted with carrier before application. The surface-active agents can be anionic, cationic or nonionic in character and can be employed as emulsifying agents, wetting agents, suspending agents, or for other purposes. Typical surface active agents include salts of alkyl sulfates, such as diethanolammonium lauryl sulfate; alkylarylsulfonate salts, such as calcium dodecylbenzenesulfonate; alkylphenol-alkylene oxide addition products, such as nonylphenol-C₁₈ ethoxylate; alcohol-alkylene oxide addition products, such as tridecyl alcohol-C₁₆ ethoxylate; soaps, such as sodium stearate; alkylnaphthalenesulfonate salts, such as sodium dibutylnaphthalenesulfonate; dialkyl esters of sulfosuccinate salts, such as sodium di(2-ethylhexyl) sulfosuccinate; sorbitol esters, such as sorbitol oleate; quaternary amines, such as lauryl trimethylammonium chloride; polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; and salts of mono and dialkyl phosphate esters.

Other adjuvants commonly utilized in agricultural compositions include compatibilizing agents, antifoam agents, sequestering agents, neutralizing agents and buffers, corrosion inhibitors, dyes, odorants, spreading agents, penetration aids, sticking agents, dispersing agents, thickening agents, freezing point depressants, antimicrobial agents, and the like. The compositions can also contain other compatible components, for example, other herbicides, herbicide safeners, plant growth regulants, fungicides, insecticides, and the like and can be formulated with liquid fertilizers or solid, particulate fertilizer carriers such as ammonium nitrate, urea and the like.

The concentration of the active ingredients in the herbicidal compositions of this invention is generally from about 0.001 to about 98 percent by weight. Concentrations from about 0.01 to about 90 percent by weight are often employed. In compositions designed to be employed as concentrates, the active ingredient is generally present in a concentration from about 5 to about 98 weight percent, preferably about 10 to about 90 weight percent. Such compositions are typically diluted with an inert carrier, such as water, before application. The diluted compositions usually applied to weeds or the locus of weeds generally contain about 0.001 to about 5 weight percent active ingredient and preferably contain about 0.01 to about 0.5 percent.

The present compositions can be applied to weeds or their locus by the use of conventional ground or aerial dusters, sprayers, and granule applicators, by addition to irrigation water, and by other conventional means known to those skilled in the art.

The compounds of Formula I have been found to be useful preemergence (including pre-plant) and postemergence herbicides. Postemergence applications are generally preferred. The compounds are effective in the control of both broadleaf and grassy weeds. While each of the N-(triazoloazinyl)arylsulfonamide compounds encompassed by Formula I is within the scope of the invention, the degree of herbicidal activity, the crop selectivity, and the spectrum of weed control obtained varies depending upon the substituents and other features present. The compounds can be employed at higher, non-selective rates of application to control essentially all of the vegetation in an area. Compounds 10, 13, 14, 15, 18, 23, 26, 27, 28, 36, 37, 38, 39, 41, 50, 53, 54, 60, 63, 65, 77, 80, 81, 92, 105, 106, and 139 are among the compounds that are of special interest for this purpose. In many cases, the compounds can also be employed at lower, selective rates of application for the control of undesirable vegetation in grass crops, such as corn, sorghum, wheat, barley, and rice as well as in broadleaf crops, such as oil-seed rape, soybeans, and cotton. Their use in the control of selective grassy weeds, such as blackgrass and wild oats, and some broadleaf weeds in small grain crops, such as wheat and barley, is of special interest. Compounds 28, 34, 53, 96, 98, 105, and 142 are among the better compounds for this purpose. Many of the compounds can be used to remove broadleaf weeds from small grain crops, such as wheat. Compounds of special interest for this purpose include compounds 1, 2, 21, 32, 43, 46, 52, 95, 109, 120, 122, and 126. Many of the compounds are also useful for the control of many broadleaf and grassy weeds in rice. Compounds of special interest for this purpose include compounds 167, 177, 184, 185, 187, 188, 190, 194, 195, 203, 209, 210, 220, 229, & 233. Undesirable vegetation can be removed from rice that is either direct seeded or transplanted and is grown either in paddies or upland. The selectity to rice can often be improved by the use of safeners. Some of the compounds, such as compounds 55 and 106, can be employed to remove broadleaf and grassy weeds from oil-seed rape.

The term herbicide is used herein to mean an active ingredient which controls or adversely modifies the growth of plants. An herbicidally effective or vegetation controlling amount is an amount of active ingredient which causes an adversely modifying effect and includes deviations from natural development, killing, regulation, desiccation, retardation, and the like. The terms plants and vegetation are meant to include germinant seeds, emerging seedlings and established vegetation.

Herbicidal activity is exhibited by the compounds of the present invention when they are applied directly to the plant or to the locus of the plant at any stage of growth or before planting or emergence. The effect observed depends upon the plant species to be controlled, the stage of growth of the plant, the application parameters of dilution and spray drop size, the particle size of solid components, the environmental conditions at the time of use, the specific compound employed, the specific adjuvants and carriers employed, the soil type, and the like, as well as the amount of chemical applied. These and other factors can be adjusted as is known in the art to promote non-selective or selective herbicidal action. Generally, it is preferred to apply the compounds of Formula I postemergence to relatively immature plants to achieve the maximum control of weeds.

Application rates of about 0.001 to about 1 Kg/Ha are generally employed in postemergence operations; for preemergence applications, rates of about 0.01 to about 2 Kg/Ea are generally employed. The higher rates designated generally give non-selective control of a broad variety of undesirable vegetation. The lower rates typically give selective control and, by judicious election of compounds, timing, and rates of application, can be employed in the locus of crops.

The compounds of the present invention (Formula I) are often applied in conjunction with one or more other herbicides to obtain control of a wider variety of undesirable vegetation. When used in conjunction with other herbicides, the presently claimed compounds can be formulated with the other herbicide or herbicides, tank mixed with the other herbicide or herbicides, or applied sequentially with the other herbicide or herbicides. Some of the herbicides that can be employed beneficially in combination with the compounds of the present invention include substituted triazolopyrimidinesulfonamide compounds, such as N-(2,6-dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide (diclosulam), N-(2-methoxycarbonyl-6-chlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide (cloransulam-methyl), and N-(2,6-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide (flumetsulam). Other herbicides such as acifluorfen, bentazon, chlorimuron, clomazone, lactofen, carfentrazone-methyl, fumiclorac, fluometuron, fomesafen, imazaquin, imazethapyr, linuron, metribuzin, fluazifop, haloxyfop, glyphosate, glufosinate, 2,4-D, acetochlor, metolachlor, sethoxydim, nicosulfuron, clopyralid, fluroxypyr, metsulfuron-methyl, amidosulfuron, tribenuron, and others can also be employed. It is generally preferred to use the compounds in conjunction with other herbicides that have a similar crop selectivity. It is further usually preferred to apply the herbicides at the same time, either as a combination formulation or as a tank mix.

The compounds of the present invention can generally be employed in combination with a wide variety of known herbicide safeners, such as cloquintocet, mefenpyr, furilazole, dichlormid, benoxacor, flurazole, fluxofenim, daimuron, dimepiperate, thiobencarb, and fenclorim, to enhance their selectivity. Herbicide safeners that act by modifying the metabolism of herbicides in plants by enhancing the activity of cytochrome P-450 oxidases are usually especially effective. This is often a preferred embodiment of the invention. The compounds can additionally be employed to control undesirable vegetation in many crops that have been made tolerant to or resistant to herbicides by genetic manipulation or by mutation and selection. For example, corn, wheat, rice, soybean, sugarbeet, cotton, canola, and other crops that have been made tolerant or resistant to herbicides in general or to herbicides that inhibit the enzyme acetolactate synthase in sensitive plants can he treated.

EXAMPLES

The following Examples are presented to illustrate the various aspects of this invention and should not he construed as limitations to the claims.

1. Preparation of 2-Propylthio-3-(trifluoromethyl)anisole

A solution of 30 mL (milliliter) (208 mmol) (millimole) of 3-(trifluoromethyl)anisole in 500 mL of dry tetrahydrofuran was cooled to -70° C. under a nitrogen blanket and 100 mL (250 mmol) of 2.5 M butyl lithium in hexane was added slowly with stirring and cooling. The reddish solution was stirred at -70° C. for 1 hour and then 42 mL (270 mmol) of dipropyl disulfide was added slowly with stirring and cooling. The resulting mixture was allowed to warm to ambient temperature over an 18-hour period. The mixture was quenched with 250 mL of saturated aqueous ammonium chloride. The organic phase was recovered, dried over magnesium sulfate, and concentrated by evaporation under reduced pressure. The yellow oil residue was fractionally distilled in a Vigreux column at 0.2 mm Hg (millimeters of mercury) (27 Pascals) to obtain 37 g (gram) (71 percent of theory) of a clear liquid product fraction boiling at 92° C. This fraction was found to be 82 percent the title compound, 10 percent the isomer 2-propylthio-5-(trifluoromethyl)anisole.

Elemental Analysis C₁₁ H₁₃ F₃ OS

Calc.: % C, 52.8; % H, 5.24; % S, 12.8

Found: % C, 52.7; % H, 5.11; % S, 11.9

NMR: ¹ H (CDCl₃): 7.02(m, 3H), 3.96(s, 3H), 2.83(t, 2H, J=7.4), 1.54-1.04(m, 2H), 0.93(t, 3H, J=7.4).

2. Preparation of 2-(Benzylthio)anisole

A solution of 25.0 g (178 mmol) of 2-methoxythiophenol in 50 mL of dry tetrahydrofuran was added dropwise to a mixture of 22.0 g (196 mmol) of potassium t-butoxide and 100 mL of tetrahydrofuran at 0° C. with stirring. A solution of 25 mL (214 mmol) of benzyl chloride in 50 mL of tetrahydrofuran was added to this with stirring and cooling and the mixture was then allowed to warm to ambient temperature and was stirred for 18 hours. The resulting mixture was concentrated by evaporation under reduced pressure and the residue was diluted with 300 mL of dichloromethane. The solution obtained was washed with water, dried over magnesium sulfate, and concentrated by evaporation under reduced pressure. The residue was the title compound, a white solid melting at 69-70° C.

Elemental Analysis C₁₄ H₁₄ OS

Calc.: % C, 73.0; % H, 6.13; % S, 13.9

Found: % C, 73.0; % H, 6.13; % S, 13.7

NMR: ¹ H (CDCl₃): 7.2(m, 7H), 6.8(m, 2H), 4.1(s, 2H), 3.90(s, 3H).

3. Preparation of Methyl 2-Propylthio-3-methoxybenzoate

A solution of 65.3 g (318 mmol) of 3-(4,4-dimethyloxazolin-2-yl)anisole in 400 mL of dry tetrahydrofuran was cooled to -70° C. and then 165.5 mL (414 mmol) of 2.5 M butyl lithium was added with cooling and stirring. The burgundy solution was warmed to -40° C. with stirring for 90 min. It was then cooled to -70° C. and a solution of 62.2 g (414 mmol) of dipropyl disulfide in 100 mL of dry tetrahydrofuran was added dropwise with stirring and cooling. The resulting mixture was allowed to warm to ambient temperature over a 90-min period and the pink, milky suspension obtained was neutralized with 300 mL of saturated aqueous ammonium chloride. The phases were separated and the organic phase was dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure. The residual gold oil was fractionally distilled at 0.6 mm Hg (80 Pascals) in a 2×10 cm (centimeter) Vigreux column to obtain 76.0 g (86 percent of theory) of 2-propylthio-3-(4,4-dimethyloxazolin-2-yl)anisole as a light yellow oil boiling at 155-157° C. (0.6 mm Hg).

NMR: ¹ H (CDCl₃): 7.25(t, 1H, J=7.8), 7.06(dd, 1H, J=7.6, 1.3), 6.90(dd, 1H, J=8.3, 1.2), 4.09(s, 2H), 3.87(s, 3H), 2.76(t, 2H, J=7.2), 1.44(m, 2H), 1.37(s, 6H), 0.89(t, 3H, J=7.4).

A suspension of 58.2 g (209 mmol) of 2-propylthio-3-(4,4-dimethyloxazolin-2-yl)anisole in 6N aqueous hydrochloric acid was heated at reflux with stirring for 18 hours. The resulting homogeneous solution was extracted with 3×100 mL of diethyl ether and the combined extracts were dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure. The resulting amber oil was purified by flash chromatography, on a silica gel column eluting with mixtures of hexane and ethyl acetate. The product-containing fractions were combined and concentrated by evaporation under reduced pressure to obtain 38.7 g (82 percent of theory of 2-propylthio-3-methoxybenzoic acid as a viscous gold oil.

NMR: ¹ H (CDCl₃): 12.3(brs, 1H), 7.55(dd, 1H, J=7.8, 1.1), 7.33 (t, 1H, J=8.1), 7.01(dd, 1H, J=8.3, 0.9), 3.88 (s, 3H), 2.80(t, 2H, J=7.5), 1.49(m, 2H), 0.90(t, 3H, J=7.3).

A suspension of 38.1 g (169 mmol) of 2-propylthio-3-methoxybenzoic acid in 100 g (843 mmol) of thionyl chloride was prepared and stirred at ambient temperature for 18 hours. The resulting solution was concentrated by evaporation under reduced pressure to obtain 39.7 g of crude acid chloride. A 8.7 g (36 mmol) portion of this was dissolved in 100 mL of dry methanol, the solution was cooled to 0° C., and 4.7 g (46 mmol) of triethylamine was added with stirring and cooling. The mixture was allowed to warm to ambient temperature over 18 hours with stirring. The resulting mixture was concentrated by evaporation under reduced pressure and the dark, oily residue was dissolved in 250 mL of diethyl ether. The ethereal solution was washed with 2×200 mL of water, dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure to obtain 8.4 g (99 percent of theory) of the title compound as a dark oil.

NMR: ¹ H (CDCl₃): 7.26(t, 1H, J=8.2), 7.03(d, 1H, J=8.4), 6.92(d, 1H, J=8.2), 3.87(s, 3H), 2.77(t, 2H, J=7.4), 1.45(m, 2H), 0.89(t, 3H, J=7.4).

4. Preparation of 2-Methoxy-3-propylthio-4-(trifluoromethyl)pyridine

A solution prepared by adding 110 mL (154 mmol) of 1.4 M methyl lithium in diethyl ether to 70 mL of dry tetrahydrofuran under a nitrogen blanket was cooled with a dry ice/acetone bath and to it was added with cooling and stirring 12.4 g (70 mmol) of 2-methoxy-4-(trifluoromethyl)pyridine and 0.92 mL (7 mmol) of diisopropylamine. The mixture was allowed to warm to -40° C. was then recooled in a dry ice/acetone bath. Dipropyl disulfide (33 mL, 210 mmol) was added dropwise with stirring and cooling. The resulting mixture was allowed to warm to ambient temperature and was then diluted with 150 mL of water and extracted with diethyl ether. The ethereal extract was dried over magnesium sulfate and concentrated by evaporation under reduced pressure. The tan oil residue was purified by chromatography on silica gel eluting with a mixture of hexane and ethyl acetate to obtain 14.1 g (80 percent of theory) of the title compound as a light yellow oil.

Elemental Analysis C₁₀ H₁₂ NF₃ OS

Calc.: % C, 47.8; % H, 4.81; % N, 5.57; % S, 12.8

Found: % C, 48.1; % H, 5.33; % N, 5.33; % S, 12.7

NMR: ¹ H (CDCl₃): 8.18(d, 1H, J=5.7), 7.12(d, 1H, J=5.7), 4.00(s, 3H), 2.85(t, 2H, J=7.4), 1.47-1.46(m, 2H), 0.93(t, 3H, J=7.2).

The following 3-propylthiopyridine compounds were prepared similarly:

2-Methoxy-3-propylthiopyridine--a colorless oil boiling at 80° C. under 0.3 mm Hg (40 Pascals) pressure;

Elemental Analysis C₉ H₁₃ OS

Calc.: % C, 59.0; % H, 7.15

Found: % C, 59.1; % H, 7.12;

2-Chloro-4-methoxy-3-propylthiopyridine--a clear oil;

NMR: ¹ H (CDCl₃): 8.21(d, 1H, J=5.6), 6.77(d, 1H, J=5.6), 3.97(s, 3H), 2.85(t, 2H, J=7.5), 1.57-1.50(m, 2H), 0.99(t, 3H, J=7.3); and

4-Chloro-2-methoxy-3-propylthiopyridine--a yellow oil;

NMR: ¹ H (CDCl₃): 7.96(d, 1H, J=5.2), 6.98(d, 1H, J=5.6), 4.02(s, 3H), 2.88(t, 2H, J=7.3), 1.54-1.51(m, 2H), 0.96(t, 3H, J=7.8).

5. Preparation of 2-Methoxy-6-(trifluoromethyl)benzenesulfonyl Chloride

A mixture containing 20.0 g (80 mmol) of an 82:10:8 mixture of 2-propylthio-3-(trifluoromethyl)anisole: 2-propylthio-5-(trifluoromethyl)anisole: unknown, 250 mL of chloroform, and 125 mL of water was cooled to 0° C. with an ice bath and 21.6 g (305 mmol) of chlorine gas was added slowly with stirring. After 2.5 hours the organic phase was separated, dried over magnesium sulfate, and concentrated by evaporation under reduced pressure. The residual clear oil was mixed with 100 mL of pentane and the mixture was allowed to stand at ambient temperature for 18 hours and under refrigeration for 3 hours to crystallize the oil. The solids were collected by filtration to obtain 11.9 g (54 percent of theory) of the title compound as white crystals melting at 86-88° C.

NMR: ¹ H (CDCl₃): 7.8(dd, 1H, J=7.9, 8.6), 7.53(d, 1H, J=7.9), 7.46(d, 1H, J=8.6), 4.1(s, 3H).

6. Preparation of 2-Methoxybenzenesulfonyl Chloride

A solution of 34.1 g (149 mmol) of 2-(benzylthio)anisole in 300 mL of chloroform was combined with 150 mL of water and the mixture cooled with an ice bath. Chlorine gas (39 g, 550 mmol) was added to this with cooling and stirring at a rate such that the temperature remained below 5° C. The ice bath was then removed and the yellow mixture was allowed to warm to ambient temperature and stir for 18 hours. The layers were then separated and the chloroform layer was dried over magnesium sulfate and concentrated by evaporation under reduced pressure. The residue was an oil that on standing formed 21.3 g (69 percent of theory) of white crystals of the title compound melting at 52-53° C.

NMR: ¹ H (CDCl₃): 7.93-7.76(m, 1H), 7.70-7.65(m, 1H), 7.13-7.06(m, 1H), 4.0(s, 3H).

7. Preparation of Methyl 2-Chlorosulfonyl-3-methoxybenzoate

A mixture of 7.8 g (32 mmol) of methyl 3-methoxy-2-propylthiobenzoate, 2.3 g (130 mmol) of water, and 30 ml, of glacial acetic acid was prepared and warmed to 45° C. Chlorine gas (7.6 g, 107 mmol) was added with stirring. The dark mixture turned light orange and the temperature rose to 75° C. After 1 hour the mixture was poured into 600 mL of ice and water and stirred until all of the ice melted. The solids present were recovered by filtration and dissolved in 500 mL of diethyl ether. The ether solution was dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure. The tan solid residue was flash chromatographed on silica gel eluting with a mixture of hexane and ethyl acetate. The product-containing fractions were combined and concentrated by evaporation under reduced pressure to obtain 5.32 g (62 percent of theory) of the title compound as a light pink solid melting at 106.5-108.5° C.

Elemental Analysis C₉ H₉ ClO₅ S

Calc.: % C, 40.8; % H, 3.43; % S, 12.1

Found: % C, 40.7; % H, 3.62; % S, 11.8

NMR: ¹ H (CDCl₃): 7.68(t, 1H, J=8.0), 7.21(d, 1H, J=8.7) 7.03(d, 1H, J=7.5), 4.05(s, 3H), 3.90(s, 3H).

8. Preparation of 2,6-Dimethoxybenzenesulfonyl Chloride

A solution of 15.0 g (108 mmol) of 1,3-dimethoxybenzene and 13.8 g (119 mmol) of N,N,N',N',-tetramethylethylenediamine in 225 mL of dry petroleum ether was prepared and cooled to 0° C. and then 47.5 mL (119 mmol) of 2.5 M butyl lithium in hexane was added with cooling and stirring. After 1 hour the mixture was cooled to about -72° C. and about 70 g (1 mol) of sulfur dioxide was added with stirring as a saturated solution in 100 mL of dry diethyl ether. The resulting light yellow mixture was warmed to 10° C. over a 2-hour period and then the sticky yellow solids present were collected by filtration and washed with several portions of dry diethyl ether. The solids were suspended in 400 mL of dry hexane, the suspension cooled to 0° C., and 14.6 g (108 mmol) of sulfuryl chloride as a solution in 200 mL of dry hexane was added with stirring and cooling. After 45 min at 0° C. the resulting pink solids were collected by filtration, washed with cold hexane, and dissolved in diethyl ether. The resulting solution was washed with 3×150 mL of cold water, dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure to obtain 19.4 g (76 percent of theory) of the title compound as a light yellow crystalline solid melting at 89-91° C.

NMR: ¹ H (CDCl₃): 7.51(t, 1H, J=8.5), 6.64(d, 2H, J=8.5), 3.92(s, 6H).

The following compound was prepared similarly:

2,4-Dimethoxypyridine-3-sulfonyl chloride--a tan solid melting at 118-120° C.;

NMR: ¹ H (CDCl₃): 8.26(d, 1H, J=5.9), 6.66(d, 1H, J=5.9), 4.11(s, 3H), 4.05(s, 3H).

9. Preparation of 2-Ethoxy-5-methylbenzenesulfonyl Chloride

A solution of 6.8 g (50 mmol) of 4-ethoxytoluene in 20 mL of dichloromethane was added to a solution of 10 mL (150 mmol) of chlorosulfonic acid in 10 mL of dichloromethane at 0° C. with cooling and stirring. The mixture was stirred 1 hour at 0° C. and was then warmed to ambient temperature and stirred another hour. The resulting tan solution was poured into 200 mL of ice water and the mixture was extracted with dichloromethane. The extract was dried over magnesium sulfate and concentrated by evaporation under reduced pressure. The residual 7.9 g (68 percent of theory) of light tan solid melting at 59-61° C. was the title compound.

NMR: ¹ H (CDCl₃): 7.71(d, 1H, J=2.2), 7.4(dd, 1H, J=8.5, 2.2), 6.95(d, 1H, J=8.5), 4.23(q, 2H, J=7.0), 1.49(t, 3H, J=7.0)

10. Preparation of 2-Methoxy-4-(trifluoromethyl)pyridine-3-sulfonyl Chloride

Fifty mL of water was combined with a solution of 7.0 g (28 mmol) of 2-methoxy-3-propylthio-4-(trifluoromethyl)pyridine in 100 mL of dichloromethane and the mixture was cooled with an ice bath. Chlorine gas (5.1 mL, 112 mmol) was added slowly with stirring and cooling. The mixture was then allowed to warm to ambient temperature and stir for 3 hours. The layers were separated and the organic layer was dried over magnesium sulfate and concentrated by evaporation under reduced pressure. The yellow oil residue was purified by chromatography on silica gel eluting with a mixture of hexane and ethyl acetate. The fractions containing product were combined and concentrated by evaporation under reduced pressure to obtain 4.9 g (64 percent of theory of the title compound as a light yellow oil.

NMR: ¹ H (CDCl₃): 8.6(d, 1H, J=5.4), 7.4(d, 1H, J=5.4), 4.2(s, 3H). The mass spectrum had a parent peak M⁺ 275.

The following pyridine-3-sulfonyl chloride compounds were prepared similarly:

4-Chloro-2-methoxypyridine-3-sulfonyl chloride;

NMR: ¹ H (CDCl₃): 8.23(d, 1H, J=5.6), 7.11(d, 1H, J=5.2), 4.17(s, 3H); mass spectrum parent peak M⁺ 275;

2-Chloro-4-methoxypyridine-3-sulfonyl chloride--a tan crystalline solid;

NMR: ¹ H (CDCl₃): 8.47(d, 1H, J=5.9), 7.03(d, 1H, J=5.9), 4.13(s, 3H); and

2-Methoxypyridine-3-sulfonyl chloride--a clear oil;

NMR: ¹ H (CDCl₃): 8.46-8.44(dd, 1H, J=1.9, 4.9), 8.22-8.19(dd, 1H, J=1.9, 7.8), 7.08-7.04(dd, 1H, J=4.9, 7.8), 4.16(s, 3H).

11. Preparation of 2-(1,1,2,2-Tetrafluoroethoxy)benzenesulfonyl Chloride

A solution containing 3.8 g (55 mmol) of sodium nitrite in 6 mL of water was added slowly with cooling and stirring to a mixture of 12.3 g (50 mmol) of 2-(1,1,2,2-tetrafluoroethoxy)aniline, 18 mL of concentrated aqueous hydrochloric acid, and 5 mL of acetic acid that was precooled to -10° C. After 45 min, the resulting mixture was added in portions to a -10° C. solution of 1.3 g (18 mmol) of cuprous chloride and 0.5 g (4 mmol) of cupric chloride in 50 mL of acetic acid saturated with sulfur dioxide (more than 12 g). The mixture was then warmed to ambient temperature and stirred for 90 min after which it was poured onto ice. The mixture obtained was extracted with diethyl ether and the extract was washed with water, dried over magnesium sulfate, and concentrated by evaporation under reduced pressure. The residue was chromatographed on silica gel eluting with a mixture of hexane and ethyl acetate. The fractions containing product were combined and concentrated by evaporation under reduced pressure to obtain 11.0 g (75 percent of theory) of the title compound as a yellow oil.

NMR: ¹ H (CDCl₃): 8.07(dd, 1H, J=1.7, 8.0), 7.76(ddd, 1H, J=7, 7.8, 8.1), 7.59(dd, 1H, J=1.2, 8.1), 7.45(ddd, 1H, J=1.2, 7.8, 8.0), 6.05(tt, 1H, J=4.0, 53.0). The mass spectrum had a parent peak M⁺ 292.

12. Preparation of 3-Amino-8-chloro-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine Hydrobromide

A solution of 40 mL (120 mmol) of 3 molar cyanogen bromide in dichloromethane was combined with 19.0 g (100 mmol) of 5-chloro-4-hydrazino-2-methylthiopyrimidine and 200 mL of dry isopropyl alcohol at ambient temperature with stirring. The resulting mixture was stirred for 18 hours and then diluted with 500 mL of diethyl ether. The solids that formed were recovered by filtration and dried to obtain the theoretical amount of the title compound as a yellow solid melting above 250° C.

Elemental Analysis C₆ H₇ N₅ BrClS

Calc.: % C, 24.3; % H, 2.38; % N, 23.6; % S, 10.8

Found: % C, 26.1; % H, 2.69; % N, 24.0; % S, 12.2;

NMR: ¹ H (DMSO-d6): 7.80(s, 1H), 2.67(s, 3H); ¹³ C: 150.96, 147.90, 143.10, 138.38, 113.16, 14.22.

The following 3-amino[1,2,4]triazolo[4,3-c]pyrimidine compounds were prepared similarly:

3-Amino-8-fluoro-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide--a yellow solid melting at 168-170° C.;

Elemental Analysis C₆ H₇ N₅ BrFS

Calc.: % C, 25.7; % H, 2.51; % N, 25.0; % S, 11.4

Found: % C, 25.7; % H, 2.52; % N, 25.0; % S, 11.5;

3-Amino-8-methoxy-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide--a tan solid melting at 180-182° C.;

Elemental Analysis C₇ H₁₀ N₅ BrOS

Calc.: % C, 28.8; % H, 3.45; % N, 24.0; % S, 11.0

Found: % C, 29.0; % H, 3.44; % N, 23.9; % S, 11.1;

3-Amino-8-iodo-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide--a yellow solid melting at 197-199° C.;

Elemental Analysis C₆ H₇ N₅ BrIS

Calc.: % C, 18.6; % H, 1.82; % N, 18.1; % S, 8.26

Found: % C, 19.0; % H, 2.28; % N, 18.0; % S, 8.54;

3-Amino-8-bromo-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide--a yellow solid melting at 193-195° C.;

Elemental Analysis C₆ H₇ N₅ Br₂ S

Calc.: % C, 21.1; % H, 2.07; % N, 20.5; % S, 9.40

Found: % C, 21.3; % H, 2.14; % N, 20.6; % S, 9.33;

3-Amino-8-methyl-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide--a yellow solid melting at 234-236° C.;

Elemental Analysis C₇ H₁₀ N₅ BrS

Calc.: % C, 30.6; % H, 3.30; % N, 25.5; % S, 11.7

Found: % C, 30.7; % H, 3.52; % N, 25.3; % S, 11.5;

3-Amino-8-ethoxy-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide--a yellow powder melting at 160-163° C.; and

3-Amino-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide--a tan solid;

NMR: ¹ H (DMSO-d6): 7.52(d, 1H, J=6.6), 7.13(d, 1H, J=6.7), 6.08(s, 2H), 2.61(s, 3H).

13. Preparation of 2-Amino-8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine

A mixture of 15.0 g (51 mmol) of 3-amino-8-chloro-5-methylthio[1,2,4]triazolo[4,3-c]pyrimidine hydrobromide, 8.2 mL (76 mmol) of ethyl acrylate, and 150 mL of methanol was prepared and cooled in an ice bath. A solution of 17 mL (76 mmol) of 4.5 molar sodium methoxide in methanol was added to this slowly with cooling and stirring. When the addition was complete, the mixture was allowed to warm to ambient temperature and was stirred for 18 hours. It was then neutralized with 2.0 mL of acetic acid. The solids that formed were recovered by filtration, washed with diethyl ether, and dried to obtain 7.7 g (75 percent of theory) of the title compound as a tan powder melting above 250° C.

Elemental Analysis C₆ H₆ N₅ ClO

Calc.: % C, 36.1; % H, 3.03; % N, 35.1%

Found: % C, 36.1; % H, 3.19; % N, 34.8%

NMR: ¹ H (DMSO-d6): 8.0(s, 1H), 6.6(brs, 2H), 4.1(s, 3H); ¹³ C 166.40, 151.65, 147.73, 140.95, 108.57, 56.12.

The following 2-amino[1,2,4]triazolo[1,5-c]pyrimidine compounds were prepared similarly:

2-Amino-8-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine--tan needles melting above 230° C.;

Elemental Analysis C₆ H₆ N₅ FO

Calc.: % C, 39.4; % H, 3.30; % N, 38.2%

Found: % C, 39.5; % H, 3.28; % N, 37.7%;

2-Amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine--a tan powder melting at 201-203° C.;

Elemental Analysis C₇ H₉ N₅ O₂

Calc.: % C, 43.1; % H, 4.65; % N, 35.9%

Found: % C, 43.2; % H, 4.67; % N, 35.6%;

2-Amino-7-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine--a tan powder melting above 250° C.;

Elemental Analysis C₆ H₆ N₅ FO

Calc.: % C, 39.4; % H, 3.30; % N, 38.2%

Found: % C, 39.6; % H, 3.31; % N, 38.2%;

2-Amino-8-iodo-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine--a tan solid melting above 250° C.;

Elemental Analysis C₆ H₆ N₅ IO

Calc.: % C, 24.8; % H, 2.08; % N, 24.1%

Found: % C, 25.0; % H, 1.96; % N, 23.8%;

2-Amino-8-methyl-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine--a tan solid melting above 250° C.;

Elemental Analysis C₇ H₉ N₅ O

Calc.: % C, 46.9; % H, 5.06; % N, 39.1%

Found: % C, 46.7; % H, 4.84; % N, 39.1%;

2-Amino-8-ethoxy-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine--a light tan solid melting at 190-191° C.; and

2-Amino-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine--a tan solid melting above 250° C.;

NMR: ¹ H (DMSO-d6): 7.82(d, 1H, J=6.3), 7.03(d, 1H, J=6.1), 6.31(s, 2H), and 4.12(s, 3H).

14. Preparation of 2-(N-Trimethylsilylamino)-8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine

A mixture of 12.7 g (85 mmol) of sodium iodide in 425 mL of dry acetonitrile was prepared under nitrogen in a predried 2 L flask and to this mixture 9.25 g (10.8 mL, 85 mmol) of chlorotrimethylsilane was added by means of a syringe at ambient temperature with stirring. After 10 min, 17.0 g (85 mmol) of 2-amino-8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine and 8.62 g (11.9 mL, 85 mmol) of triethylamine were added with stirring. The mixture was allowed to react for 12 hours at ambient temperature with stirring and was then diluted with 500 mL of dry diethyl ether. The salts that precipitated were removed by filtration on a dry scintered glass filter and the filtrate was concentrated by evaporation under reduced pressure. The residue was diluted with another 500 mL of dry diethyl ether the salt removal procedure was repeated. The title compound was obtained as the solid residue and amounted to 19.5 g (84 percent of theory).

15. Preparation of (N-(8-Chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-2-methoxy-6-(trifluoromethyl)benzenesulfonamide

A solution of 19.5 g (72 mmol) of 2-(N-trimethylsilylamino)-8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine dissolved in 150 mL of dry acetonitrile was prepared and 27.5 g (100 mmol) of 2-methoxy-6-(trifluoromethyl)benzenesulfonyl chloride was added at ambient temperature under nitrogen with stirring. To this was added sequentially with stirring 6.7 g (6.9 mL, 85 mmol) of dry pyridine, 0.66 g (0.60 mL, 8.5 mmol) of dry dimethyl sulfoxide, and 13.7 g (85 mmol) of cesium fluoride. The mixture was allowed to react for 8 hours and then the solids present were recovered by filtration. These solids were slurried in 100 mL of 0.38 percent aqueous hydrochloric acid and recovered by filtration and then slurried in 100 mL of methanol and recovered by filtration. The white solid recovered was dried to obtain 21.3 g (68 percent of theory) of the title compound melting at 216-217° C.

Elemental Analysis C₁₄ H₁₁ N₅ ClF₃ O₄ S

Calc.: % C, 38.4; % H, 2.53; % N, 16.0

Found: % C, 38.6; % H, 2.50; % N, 16.1

16. Preparation of (N-(8-Chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-2,6-dimethoxybenzenesulfonamide

A suspension of 0.80 g (4.0 mmol) of 2-amino-8-chloro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine in 15 mL of dry acetonitrile was prepared and 1.90 g (8.0 mmol of 2,6-dimethoxybenzenesulfonyl chloride, 0.63 g (8.0 mmol) of dry pyridine, and 0.08 g (1 mmol) of dry dimethyl sulfoxide were added with stirring at ambient temperature, keeping the system dry. After 18 hours another 0.32 g of dry pyridine was added and after another 18 hours another 0.08 g of dry dimethyl sulfoxide was added. After 1 more hour the mixture was diluted with 350 mL of dichloromethane and the resulting mixture was washed with 3×150 mL of water, dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure. The orange oil residue was triturated with diethyl ether to obtain the title compound as a light yellow solid which, after drying, amounted to 1.41 g (88 percent of theory) and melted at 215.5-217.5.

Elemental Analysis C₁₄ H₁₄ N₅ ClO₅ S

Calc.: % C, 42.1; % H, 3.53; % N, 17.5; % S, 8.02

Found: % C, 42.2; % H, 3.62; % N, 17.1; % S, 7.70

NMR: ¹ H (DMSO-d6): 11.74(S, 1H), 8.10(s, 1H), 7.44(t, 1H, J=8.5), 6.75(d, 2H, J=8.4), 4.11(s, 3H), 3.88(s, 3H), 3.77(s, 6H).

17. Preparation of 2-Carbomethoxy-6-methoxy-(N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide

A suspension of 0.70 g (3.5 mmol) of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine in 15 mL of dry acetonitrile was prepared and 1.84 g (7.0 mmol of methyl 2-chlorosulfonyl-3-methoxybenzoate, 0.55 g (7.0 mmol) of dry pyridine, and 0.07 g (0.9 mmol) of dry dimethyl sulfoxide were added with stirring at ambient temperature, keeping the system dry. After 18 hours another 0.92 g of dry pyridine and 0.07 g of dry dimethyl sulfoxide were added, after another 36 hours another 0.92 g of dry pyridine was added, and after another 18 hours another 0.92 g of dry pyridine and another 0.07 g of dry dimethyl sulfoxide were added. After 18 more hours the mixture was diluted with 300 mL of dichloromethane. The organic phase was recovered and washed with 2×200 mL of water and 2×200 mL of 2 N aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure. The tan solid residue was triturated with diethyl ether to obtain the title compound as an 80 percent purity white solid. This solid was chromatographed twice on a silica gel column, eluting with a dichloromethane/ethanol/acetic acid mobile phase (which was largely unsuccessful) and was then recrystallized from hot methanol. The product obtained was 0.274 g (19 percent of theory) of shiny white needles melting at 215-217° C.

Elemental Analysis C₁₆ H₁₇ N₅ O₇ S

Calc.: % C, 45.4; % H, 4.05; % N, 16.5; % S, 7.57

Found: % C, 44.7; % H, 3.96; % N, 16.2; % S, 7.93

NMR: ¹ H (DMSO-d6): 11.76(s, 1H), 7.60(t, 1H, J=8.3), 7.28(d, 1H, J=8.3), 7.05(d, 1H, J=7.6), 4.07(s, 3H), 3.88(s, 3H), 3.81(s, 3H), 3.78(s, 3H).

18. Preparation of 2,6-Dimethoxy-(N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide

A suspension of 0.80 g (4.1 mmol) of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine in 15 mL of dry acetonitrile was prepared and 1.94 g (8.2 mmol of 2,6-dimethoxybenzenesulfonyl chloride, 0.65 g (8.2 mmol) of dry pyridine, and 0.08 g (1 mmol) of dry dimethyl sulfoxide were added at ambient temperature with stirring, keeping the system dry. After 24 hours the mixture was diluted with 200 mL of dichloromethane. The organic phase was recovered and washed with 2×200 mL of water and 2×200 mL of 2 N aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure. The orange solid residue was dissolved in 5 mL of dichloromethane and then diethyl ether was added dropwise with stirring. The gray solid that formed was recovered by filtration, washed with ether, and dried at 50° C. under reduced pressure to obtain 1.11 g (68 percent of theory) of title compound as an off-white solid melting at 239-240.5° C.

Elemental Analysis C₁₅ H₁₇ N₅ O₆ S

Calc.: % C, 45.6; % H, 4.33; % N, 17.7%

Found: % C, 45.7; % H, 4.19; % N, 17.6%

NMR: ¹ H (DMSO-d6): 11.54(s, 1H), 7.55(s, 1H), 7.44(t, 1H, J=8.4), 6.74(d, 2H, J=8.4), 4.06(s, 3H), 3.88(s, 3H), 3.76(s, 6H).

19. Preparation of 2-Methoxy-5-methyl-(N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide

A mixture of 1.0 g (5.1 mmol) of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine, 2.1 g (10 mmol) of 2-methoxy-5-methylbenzenesulfonyl chloride, and 15 mL of dry acetonitrile was prepared and to this was added at ambient temperature with stirring and means to keep the system dry 0.8 mL (10 mmol) of dry pyridine and 71 microliters (1.0 mmol) of dry dimethyl sulfoxide. The mixture was allowed to stir for 18 hours and then another 1.0 g (5.0 mmol) of 2-methoxy-5-methylbenzenesulfonyl chloride was added. Stirring was continued another 24 hours at which time another 0.4 mL of dry pyridine and 35 microliters of dry dimethyl sulfoxide were added. After stirring another 9 days, the volatiles were removed by evaporation under reduced pressure. The dark residue was diluted with 50 mL of water and 50 mL of diethyl ether and the solids were recovered by filtration. The solids were slurried in dichloromethane and after 2 hours of stirring were recovered by filtration to obtain 1.2 g (63 percent of theory) of the title compound as a white powder melting at 217-219° C.

Elemental Analysis C₁₅ H₁₇ N₅ O₅ S

Calc.: % C, 47.5; % H, 4.52; % N, 18.5; % S, 8.45

Found: % C, 47.7; % H, 4.61; % N, 18.3; % S, 8.80

NMR: ¹ H (DMSO-d6): 12.0(brs, 1H), 8.1(s, 1H), 7.7(t, 1H, J=8.2), 7.56-7.52(m, 2H), 4.06(s, 3H), 4.1(s, 3H), 3.9(s, 3H).

20. Preparation of N-(5,8-Dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)-3-pyridinesulfonamide

A mixture of 0.75 g (93.8 mmol) of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine, 2.1 g (7.6 mmol) of 2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonyl chloride, and 10 mL of dry acetonitrile was prepared and to this was added at ambient temperature with stirring and means to exclude moisture from the system 0.61 mL (7.6 mmol) of dry pyridine, 43 microliters (0.6 mmol) of dry dimethyl sulfoxide, and a small quantity of dry 4A molecular sieves. The mixture was stirred for 5 days. Another 1.0 g (3.4 mmol) of 2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonyl chloride and 0.30 mL (3.5 mmol) of dry pyridine were added and the mixture stirred another 2 days. Another 0.30 mL (3.5 mmol) of dry pyridine was added and stirring continued for 4 more days. The mixture was then diluted with 100 mL of dichloromethane and the resulting mixture was washed with 2×100 mL of 2N aqueous hydrochloric acid, dried over magnesium sulfate, and concentrated by evaporation under reduced pressure. The tan solid residue was chromatographed on silica gel eluting with a mixture of dichloromethane and ethanol to obtain 0.90 g (54 percent of theory) of the title compound as a white solid melting at 214-216° C.

Elemental Analysis C₁₄ H₁₃ N₆ F₃ O₅ S

Calc.: % C, 38.7; % H, 3.02; % N, 19.4; % S, 7.38

Found: % C, 38.5; % H, 3.15; % N, 19.4; % S, 7.43

NMR: ¹ H (DMSO-d6): 12.3(brs, 1H), 8.64(d, 1H, J=5.3), 7.60-7.58(m, 2H), 4.06(s, 3H), 3.95(s, 3H), 3.86(s, 3H).

21. Preparation of 2-Methoxycarbonyl-6-methoxy-(N-(5-chloro-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzenesulfonamide

A mixture of 0.90 g (4.5 mmol) of 2-amino-5-chloro-8-methoxy[1,2,4]triazolo[1,5-a]pyridine and 35 mL of dry acetonitrile was prepared and 2.39 g (9.06 mmol) of methyl 2-chlorosulfonyl-3-methoxybenzoate, 0.72 g (9.1 mmol) of dry pyridine, and 0.071 g (0.91 mmol) of dimethyl sulfoxide were added with stirring at ambient temperature keeping the system dry. After 16 hours another 0.35 g (4.5 mmol) of dry pyridine was added and after an additional 48 hours the volatile components of the mixture were removed by evaporation under reduced pressure. The residue obtained was diluted with 50 mL of dichloromethane and 50 mL of 2N aqueous hydrochloric acid and the mixture was stirred vigorously for 72 hours. The solids present were recovered by filtration and washed with 3×25 mL of water, 3×10 mL of dichloromethane, and 3×10 mL of diethyl ether to obtain the title compound as a white solid. The total filtrate and washes were combined and were diluted with 25 mL of dichloromethane and 25 mL of 2N aqueous hydrochloric acid in a separatory funnel. The phases were separated and the organic phase was washed with 3×50 mL of 2N aqueous hydrochloric acid. It was then dried over sodium sulfate, filtered, and concentrated by evaporation under reduced pressure to obtain a yellow solid. This was suspended in 5.0 mL of dichloromethane and the solids were recovered by filtration and washed quickly with 2×5.0 mL of dichloromethane and 2×15 mL of diethyl ether to obtain additional title compound as a white solid. The combined title compound amounted to 1.09 g (56 percent of theory) and melted at 290-292° C. with decomposition.

Elemental Analysis C₁₆ H₁₅ N₄ ClO₆ S

Calc.: % C, 45.0; % H, 3.45; % N, 13.1; % S, 7.51

Found: % C, 44.9; % H, 3.39; % N, 12.8; % S, 7.79

NMR: ¹ H (DMSO-d6): 11.60(s, 1H), 7.62(t, 1H, J=7.69), 7.24(m, 2H), 7.05(m, 2H), 3.92(s, 3H), 3.83(s, 3H), 3.77(s, 3H).

22. Preparation of 2-Methoxycarbonyl-6-methoxy-(N-(5,8-dimethoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzenesulfonamide

A 0.871 g (2.04 mmol) sample of 2-methoxycarbonyl-6-methoxy-(N-(5-chloro-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzenesulfonamide was placed in a dry, closed flask with rubber and glass stoppers. This was dissolved in 20 mL of dry dimethyl sulfoxide added by means of a cannula and 1.39 mL of 6.12 M sodium methoxide in methanol was added by means of a syringe with stirring at ambient temperature. After 16 hours another 0.050 mL of sodium methoxide solution was added and the reaction was allowed to proceed another 18 hours. Sufficient glacial acetic acid was added to make the mixture acidic and then the mixture was poured into 250 mL of dichloromethane. The resulting mixture was washed with 6×200 mL of water, dried over sodium sulfate, filtered, and concentrated by evaporation under reduced pressure. The white solid residue obtained was dissolved in 600 mL of dichloromethane and purified by silica gel column chromatography, eluting with mixtures of dichloromethane and ethanol starting with a 99:1 v/v mixture and increasing the amount of ethanol with time. The fractions containing product were combined and concentrated by evaporation under reduced pressure to obtain 496 mg (57 percent of theory) of the title compound as an off-white solid melting at 274-276° C. with decomposition.

Elemental Analysis C₁₇ H₁₈ N₄ O₇ S

Calc.: % C, 48.3; % H, 4.30; % N, 13.3; % S, 7.59

Found: % C, 48.6; % H, 4.26; % N, 13.1; % S, 7.83

NMR: ¹ H (DMSO-d6): 11.33(s, 1H), 7.61(t, 1H, J=8.06), 7.28(d, 1H, J=8.51), 7.02(d, 2H, J=7.94), 6.42(d, 1H, J=8.55), 3.98(s, 3H), 3.85(s, 3H), 3.82(s, 3H), 3.75(s, 3H).

23. Evaluation of Postemergence Herbicidal Activity

Seeds of the desired test plant species were planted in Grace-Sierra MetroMix® 306 planting mixture, which typically has a pH of 6.0 to 6.8 and an organic matter content of about 30 percent, in plastic pots with a surface area of 64 square centimeters. When required to ensure good germination and healthy plants, a fungicide treatment and/or other chemical or physical treatment was applied. The plants were grown for 7-21 days in a greenhouse with an approximately 15 hr photo period which was maintained at about 23-29° C. during the day and 22-28° C. during the night. Nutrients and water were added on a regular basis and supplemental lighting was provided with overhead metal halide 1000 Watt lamps as necessary. The plants were employed for testing when they reached the first or second true leaf stage.

A weighed amount of each test compound, determined by the highest rate to be tested, was placed in a 20 mL glass vial and was dissolved in 4 mL of a 97:3 v/v (volume/volume) mixture of acetone and dimethyl sulfoxide to obtain concentrated stock solutions. If the test compound did not dissolve readily, the mixture was warmed and/or sonicated. The concentrated stock solutions obtained were diluted with an aqueous mixture containing acetone, water, isopropyl alcohol, dimethyl sulfoxide, Atplus 411E crop oil concentrate, and Triton X-155 surfactant in a 48.5:39:10:1.5:1.0:0.02 v/v ratio to obtain spray solutions of known concentration. The solutions containing the highest concentration to be tested were prepared by diluting 2 mL aliquots of the stock solution with 13 mL of the mixture and lower concentrations were prepared by dilution of appropriate smaller portions of the stock solution. Approximately 1.5 mL aliquots of each solution of known concentration were sprayed evenly onto each of the test plant pots using a DeVilbiss atomizer driven by compressed air pressure of 2 to 4 psi (140 to 280 kilopascals) to obtain thorough coverage of each plant. Control plants were sprayed in the same manner with the aqueous mixture. In this test an application rate of 1 ppm results in the application of approximately 1 g/Ha.

The treated plants and control plants were placed in a greenhouse as described above and watered by sub-irrigation to prevent wash-off of the test compounds. After 2 weeks the condition of the test plants as compared with that of the untreated plants was determined visually and scored on a scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete kill. Some of the compounds tested, application rates employed, plant species tested, and results are given in Table 2.

                                      TABLE 2                                      __________________________________________________________________________     POSTMERGENCE HERBICIDAL ACTIVITY                                               Cpd. Rate,                                                                       No.  ppm BWCHK BWCKB BWLMQ BWMGL BWPIG BWVEL BWVIO BWWBK GWBLG GWGFT                                                                   GWROX GWWOT          __________________________________________________________________________      1 125                                                                              --   100  99   100  95  99   --  83   50   85   --   55                      2 62.5 -- 100 95 100 95 75 -- 83 80 93 -- 70                                   3 125 -- 90 85 99 95 70 -- 80 20 70 -- 0                                       4 125 -- 97 97 83 90 80 -- 70 10 93 -- 0                                       5 31.3 90 85 80 85 100 80 80 80 60 75 -- 75                                    6 15.6 -- 98 98 85 100 90 -- 90 70 50 -- 70                                    7 62.5 -- 100 98 90 80 95 -- -- 75 50 -- 99                                    8 125 -- 98 95 98 80 95 -- 80 85 78 -- 90                                      9 125 -- >100 90 90 90 85 -- -- 60 75 -- 75                                    10 1.95 100 98 95 70 100 85 80 -- 80 75 90 98                                  11 31.3 80 95 88 90 90 90 75 85 30 75 78 50                                    12 31.3 90 100 90 80 85 90 85 85 85 85 85 85                                   13 3.9 85 100 65 88 80 90 80 85 75 85 90 90                                    14 15.6 100 90 85 90 95 75 85 90 90 90 90 90                                   15 7.8 75 100 75 88 100 55 85 80 75 75 90 90                                   16 125 98 98 -- 98 100 98 60 88 15 0 78 0                                      17 15.6 90 100 100 75 98 -- 75 65 95 80 93 78                                  18 3.9 85 100 85 88 95 85 85 90 75 85 90 88                                    19 7.8 100 100 65 80 100 65 75 80 70 60 85 98                                  20 250 -- 90 95 75 85 100 -- 80 30 0 -- 20                                     21 31.3 -- 100 99 75 97 75 -- 99 50 70 -- 60                                   22 7.8 90 90 -- 98 100 95 90 80 50 40 90 78                                    23 15.6 -- 100 99 97 97 99 -- 90 75 95 -- 95                                   24 31.3 98 100 70 90 90 90 85 90 50 90 60 80                                   25 31.3 75 100 85 80 90 75 75 85 65 75 90 80                                   26 2.0 90 98 100 78 100 80 78 75 75 50 95 90                                   27 7.8 88 100 100 80 95 95 70 93 85 78 98 90                                   28 1.0 80 100 100 78 98 80 80 80 93 -- 70 75                                   29 125 85 98 -- 80 100 90 75 20 50 40 85 50                                    30 7.8 70 100 80 95 90 85 58 80 40 80 85 80                                    31 15.6 100 100 80 95 80 90 85 80 75 40 80 98                                  32 31.3 95 98 -- 85 95 90 95 60 0 0 30 0                                       33 7.8 90 95 95 90 95 88 85 85 60 80 85 78                                     34 7.8 100 100 65 75 95 90 85 100 90 50 80 95                                  35 125 90 100 95 98 95 98 70 100 60 30 80 95                                   36 3.9 90 90 100 78 100 70 78 75 60 95 90 90                                   37 15.6 95 78 100 95 100 90 95 80 78 98 95 90                                  38 3.9 98 95 100 80 100 90 78 90 85 60 98 98                                   39 3.9 95 100 100 90 90 70 80 80 70 60 80 78                                   40 15.6 95 100 100 90 95 90 78 78 65 80 78 78                                  41 7.8 98 90 95 85 95 90 90 90 85 90 98 80                                     42 15.6 100 100 78 90 95 90 50 78 75 40 20 75                                  43 31.3 95 100 30 95 95 95 95 90 50 75 30 55                                   44 3.9 95 100 55 90 90 78 60 78 45 20 35 60                                    45 7.8 90 100 55 95 98 60 75 80 35 50 30 0                                     46 62.5 100 100 75 90 100 100 95 95 70 70 45 55                                47 7.8 85 95 100 80 95 80 60 85 55 90 80 80                                    48 62.5 95 100 78 90 95 98 95 50 90 20 90 30                                   49 15.6 95 95 100 80 90 90 90 90 65 30 70 90                                   50 2.0 100 90 70 90 100 70 90 85 -- 40 95 85                                   51 62.5 95 90 70 78 95 50 85 90 90 100 95 100                                  52 7.8 100 100 65 75 95 95 78 95 78 45 0 70                                    53 31.3 -- 95 60 85 100 90 90 78 90 95 95 95                                   54 15.6 100 90 80 78 100 55 90 90 100 80 95 95                                 55 0.5 85 100 100 75 98 75 70 80 45 60 75 80                                   56 62.5 90 100 80 85 95 90 85 90 80 78 95 90                                   57 125 95 90 65 80 85 80 45 80 85 50 80 55                                     58 62.5 95 85 78 B5 100 90 90 80 95 78 95 95                                   59 7.8 100 100 78 80 100 90 95 95 95 25 95 90                                  60 2.0 95 100 65 60 90 90 60 78 70 80 80 70                                    61 250 80 95 90 78 70 85 85 85 70 20 30 20                                     62 31.3 80 90 95 90 100 95 80 85 78 90 90 90                                   63 31.3 95 90 95 90 100 78 90 90 90 90 95 90                                   64 31.3 65 85 95 80 90 65 80 80 70 85 70 80                                    65 15.6 95 95 100 90 100 95 90 90 90 90 95 100                                 66 62.5 95 60 85 78 90 90 85 90 90 80 90 90                                    67 31.3 100 70 95 90 85 90 90 80 85 70 90 85                                   68 62.5 90 70 100 90 100 85 85 78 80 90 90 85                                  69 31.3 65 55 60 55 85 70 40 90 65 60 65 60                                    70 7.8 80 100 78 90 95 95 90 70 95 70 90 80                                    71 7.8 75 95 95 90 90 90 80 70 80 60 90 60                                     72 15.6 90 95 95 50 90 78 75 90 90 80 95 78                                    73 15.6 95 80 100 70 70 80 75 90 70 65 90 75                                   74 2.0 90 80 95 85 100 80 70 78 78 75 85 78                                    75 2.0 75 100 100 90 90 95 75 90 70 50 70 75                                   76 31.3 78 90 95 90 100 90 85 85 85 50 100 90                                  77 15.6 95 90 70 78 95 85 95 95 95 95 95 95                                    78 15.6 90 78 80 90 100 95 90 95 78 30 80 90                                   79 250 65 80 80 78 95 75 80 90 80 100 85 90                                    80 1.0 95 95 100 85 100 80 78 90 70 90 60 70                                   81 3.9 90 90 95 95 100 90 75 90 78 80 80 95                                    82 31.3 95 85 75 90 100 90 90 80 80 0 78 78                                    83 15.6 90 98 80 80 50 35 20 80 0 20 10 0                                      84 7.8 80 95 95 85 100 85 78 90 70 45 60 78                                    85 7.8 95 95 60 75 80 90 70 80 78 30 30 80                                     86 31.3 90 80 95 80 85 70 85 90 65 0 78 78                                     87 31.3 95 85 80 78 90 90 80 90 80 70 75 90                                    88 125 95 70 60 90 95 80 80 95 75 40 60 40                                     89 125 85 90 80 90 90 85 90 90 85 80 80 70                                     90 62.5 90 90 95 65 90 80 78 90 75 20 80 75                                    91 125 90 78 70 78 95 80 90 90 80 65 90 90                                     92 3.9 90 85 90 90 90 75 70 80 70 70 90 78                                     93 31.3 95 85 95 90 95 65 70 85 60 80 85 78                                    94 15.6 85 85 95 90 95 85 78 90 78 90 90 75                                    95 31.3 90 100 30 95 95 95 80 90 78 40 30 45                                   96 31.3 95 95 60 90 100 90 78 90 90 60 78 80                                   98 62.5 95 70 60 85 95 90 90 90 90 95 95 95                                    99 62.5 100 100 100 80 100 80 80 85 78 90 80 78                               100 15.6 98 100 100 90 78 60 70 78 50 60 50 40                                 101 250 90 20 70 78 90 70 50 85 0 0 0 0                                        102 62.5 85 90 90 90 98 80 60 78 0 50 55 20                                    103 125 45 75 85 78 78 65 60 90 0 50 75 25                                     104 125 95 100 95 78 90 95 60 95 0 30 40 20                                    105 15.6 90 100 100 88 100 90 88 85 88 90 90 90                                106 15.6 90 95 80 70 90 75 85 80 90 85 90 90                                   107 250 80 95 88 60 95 40 75 80 70 50 88 85                                    108 62.5 90 100 90 65 85 85 80 80 85 70 88 90                                  109 31.3 90 100 75 85 90 85 70 75 10 20 85 D                                   110 31.3 95 98 40 90 70 80 55 70 20 0 55 30                                    111 15.6 85 100 -- 40 100 80 90 85 90 50 90 83                                 112 250 83 100 -- 50 100 88 88 80 90 50 90 90                                  113 250 78 100 90 70 95 60 83 50 70 30 80 75                                   114 15.6 80 100 -- 75 100 50 75 95 88 85 85 88                                 115 250 88 100 -- 50 100 83 88 88 88 20 90 88                                  116 250 78 90 -- 85 100 75 90 70 65 25 90 60                                   117 7.8 90 100 98 80 95 75 88 80 80 25 88 90                                   118 15.6 90 100 100 78 98 93 65 95 85 15 85 80                                 119 125 90 100 -- 70 80 80 90 90 60 20 90 90                                   120 31.3 85 95 95 80 100 85 85 90 80 50 85 80                                  121 7.8 99 100 100 70 95 78 70 78 55 40 78 75                                  122 15.6 85 100 -- 70 100 80 95 80 50 0 85 25                                  123 15.6 95 100 -- 70 95 85 90 85 75 95 90 95                                  124 250 78 -- 90 50 90 50 60 70 50 30 85 65                                    125 125 85 100 80 50 90 20 50 80 30 30 85 40                                   126 15.6 95 100 100 80 100 75 70 78 0 0 55 10                                  127 7.8 100 90 95 35 95 55 75 90 80 60 90 75                                   128 15.6 100 90 95 0 95 25 50 70 78 0 70 30                                    129 7.8 95 95 65 0 95 50 50 80 78 50 65 78                                     130 62.5 95 90 100 80 95 85 80 85 78 55 85 75                                  131 15.6 80 95 95 75 95 95 75 90 75 20 90 60                                   132 31.3 95 100 100 78 95 95 90 95 90 50 85 90                                 133 15.6 95 85 95 70 100 80 75 78 78 30 90 90                                  134 7.8 98 100 98 78 90 99 85 90 95 50 95 95                                   135 31.3 100 90 -- 100 100 -- 88 75 0 0 70 0                                   136 3.9 85 100 -- 90 100 70 78 90 35 20 78 60                                  137 125 90 80 60 75 95 65 85 85 95 55 95 80                                    138 15.6 95 90 90 90 95 90 85 80 55 75 90 65                                   139 3.9 100 70 100 90 95 90 95 90 80 50 90 90                                  140 125 95 90 80 95 100 95 85 90 85 40 80 90                                   141 31.3 85 88 95 90 100 78 85 78 78 88 90 85                                  142 3.9 95 95 100 80 95 95 95 80 75 50 50 75                                   143 62.5 90 90 90 90 100 95 78 90 85 90 80 80                                  144 62.5 90 40 95 78 100 78 60 75 80 80 80 75                                  145 250 60 50 80 90 100 80 -- 80 78 75 78 70                                   146 7.8 95 40 40 78 80 90 90 85 20 10 70 0                                     147 31.3 90 85 50 85 70 90 85 80 0 40 90 60                                    148 31.3 90 90 50 80 70 90 90 70 0 0 0 0                                       149 31.3 70 90 20 80 30 90 85 85 50 0 50 15                                    150 3.9 100 80 60 85 90 90 90 75 90 90 70 78                                   151 62.5 90 80 20 55 65 70 55 75 78 60 78 60                                   152 125 80 60 20 20 60 20 0 20 10 20 0 20                                      153 250 -- 45 -- 80 80 85 0 80 40 70 50 0                                      154 125 80 90 45 70 80 65 50 80 0 0 30 0                                       155 31.3 95 85 90 78 95 90 95 100 70 100 90 95                                 156 7.8 80 90 75 78 95 80 80 90 95 100 100 95                                  157 31.3 50 80 50 70 80 20 70 60 50 70 80 60                                   158 15.6 95 90 60 80 80 85 75 95 55 40 55 60                                   159 15.6 95 90 75 78 100 90 70 90 78 100 95 85                                 160 62.5 85 90 50 40 90 90 70 90 60 50 80 20                                   161 31.3 85 70 80 30 60 50 90 80 70 30 90 80                                   162 62.5 90 85 60 20 80 65 78 95 50 20 70 0                                    163 62.5 95 80 90 20 95 70 70 80 90 78 90 90                                   164 31.3 90 80 85 80 100 75 85 80 75 70 90 90                                  165 31.3 90 95 60 60 90 78 75 85 70 30 95 80                                   168 15.6 85 90 60 70 85 90 80 95 60 30 0 10                                    169 125 30 70 60 40 90 70 70 70 80 30 90 80                                    172 15.6 98 85 90 75 85 80 80 90 90 80 70 45                                   175 15.6 -- 85 85 75 85 55 80 90 95 30 70 90                                   177 15.6 98 100 -- 90 100 90 95 100 75 -- 50 25                                181 31.3 70 85 85 75 95 70 75 75 70 80 75 20                                   182 16.5 70 95 0 85 30 85 70 40 65 0 65 75                                     183 31.3 90 95 85 85 100 90 40 85 80 70 95 75                                  184 7.8 95 100 95 90 100 100 95 90 70 -- 0 0                                   185 2.0 85 100 95 75 90 75 80 80 30 0 0 0                                      186 125 75 85 70 75 75 45 70 55 90 45 70 30                                    187 1.0 95 100 90 80 75 -- 0 75 0 65 0 0                                       188 31.3 80 100 55 75 95 100 80 75 30 30 40 20                                 189 31.3 -- 100 95 75 78 70 75 100 0 20 0 0                                    190 31.3 70 90 85 60 85 85 75 90 40 80 10 30                                   191 7.8 80 95 80 80 95 20 75 90 90 75 90 90                                    192 31.3 -- 95 78 55 100 15 20 90 60 30 45 78                                  193 62.5 -- 95 100 25 95 25 20 80 45 30 75 75                                  194 2.0 80 100 80 80 85 65 75 75 30 25 0 0                                     195 7.8 75 100 90 90 100 85 80 90 0 75 30 0                                    196 7.8 100 95 75 75 100 70 85 95 80 70 95 90                                  197 2.0 90 95 75 80 100 65 75 95 95 100 95 95                                  198 3.9 90 100 95 70 100 0 60 80 85 30 80 80                                   199 2.0 75 100 80 80 100 70 80 80 20 20 0 0                                    200 3.9 100 95 100 90 100 80 95 90 60 80 95 90                                 201 15.6 -- 95 100 60 100 45 75 85 90 75 95 90                                 202 15.6 95 100 100 100 95 90 85 90 25 40 0 35                                 203 3.9 95 95 75 55 95 60 25 100 25 0 0 0                                      204 7.8 100 100 95 80 75 100 80 65 90 55 45 45                                 205 15.6 95 95 95 95 100 95 80 100 40 20 15 0                                  206 62.5 95 100 40 85 100 100 85 85 50 0 60 15                                 208 15.6 100 100 100 85 100 90 100 100 70 70 25 15                             209 31.3 100 90 -- 70 95 80 85 90 40 -- 0 0                                    210 62.5 95 95 100 90 100 95 100 90 70 -- 55 55                                211 7.8 95 90 90 80 90 70 90 90 0 -- 0 0                                       212 3.9 100 85 100 40 90 70 90 85 100 70 100 90                                215 31.3 80 95 -- 95 100 80 75 85 70 80 100 95                                 216 250 60 40 40 70 70 70 75 80 90 85 90 85                                    218 31.3 95 95 95 80 95 85 45 85 60 98 85 80                                 __________________________________________________________________________      BWCHK = chickweed (Stellaria media)                                            BWLMQ = lambsguarters (Chenopodium album)                                      BWPIG = pigweed (Amaranthus retroflexus)                                       BWVIO = viola (Viola tricolor)                                                 GWBLG = blackgrass (Alopecurus myosuroides)                                    GWROX = Rox orange sorghum (Sorghum bicolor)                                   BWCKB = cocklebur (Xanthium strumarium)                                        BWMGL = morningglory (Ipomoea hederacea)                                       BWVEL = velvetleaf (Abutilion theophrasti)                                     BWWBK = wild buckwheat (Polygonum convolvulus)                                 GWGFT = giant foxtail (Setaria faberi)                                         GWWOT = wild oats (Avena fatua)                                          

24. Evaluation of Preemergence Herbicidal Activity

Seeds of the desired test plant species were planted in a soil matrix prepared by mixing a loam soil which was composed of about 43 percent silt, 19 percent clay, and 38 percent sand and had a pH of about 8.1 and an organic matter content of about 1.5 percent and sand in a 70 to 30 ratio. The soil matrix was contained in plastic pots with a surface area of 161 square centimeters. When required to ensure good germination and healthy plants, a fungicide treatment and/or other chemical or physical treatment was applied.

A weighed amount, determined by the highest rate to be tested, of each test compound was placed in a 20 mL glass vial and was dissolved in 8 mL of a 97:3 v/v (volume/volume) mixture of acetone and dimethyl sulfoxide to obtain concentrated stock solutions. If the test compound did not dissolve readily, the mixture was warmed and/or sonicated. The stock solutions obtained were diluted with a 99.9:0.1 mixture of water and Tween® 155 surfactant to obtain application solutions of known concentration. The solutions containing the highest concentration to be tested were prepared by diluting 4 mL aliquots of the stock solution with 8.5 mL of the mixture and lower concentrations were prepared by dilution of appropriate smaller portions of the stock solution. A 2.5 mL aliquot of each solution of known concentration was sprayed evenly onto the soil of each seeded pot using a Cornwall 5.0 mL glass syringe fitted with a TeeJet TN-3 hollow cone nozzle to obtain thorough coverage of the soil in each pot. Control pots were sprayed in the same manner with the aqueous mixture. A highest application rate of 4.48 Kg/Ha is achieved when 50 mg of test compound is employed.

The treated pots and control pots were placed in a greenhouse with an approximately 15 hr photoperiod which was maintained at about 23-29° C. during the day and 22-28° C. during the night. Nutrients and water were added on a regular basis and supplemental lighting was provided with overhead metal halide 1000 Watt lamps as necessary. The water was added by top-irrigation. After 3 weeks the condition of the test plants that germinated and grew as compared with that of the untreated plants that germinated and grew was determined visually and scored on a scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete kill or no germination. Some of the compounds tested, application rates employed, plant species tested, and results are given in Table 3.

                                      TABLE 3                                      __________________________________________________________________________     PREEMERGENCE HERBICIDAL ACTIVITY                                               __________________________________________________________________________     Cpd.                                                                               Rate,                                                                        No. Kg/Ha BWCKB BWLMQ BWMGL BWPIG BWVEL BWWPT                                __________________________________________________________________________       1 0.28 -- -- 70 100 50 --                                                      2 0.28 -- -- 60 95 40 --                                                       3 0.28 -- -- 30 100 0 --                                                       4 0.28 -- -- 40 95 40 --                                                       5 0.14 95 98 90 98 90 --                                                       6 0.14 -- -- 80 98 95 --                                                       7 0.14 -- -- 80 98 85 --                                                       8 0.14 -- -- 60 90 60 --                                                       9 0.14 -- -- 90 95 85 --                                                       10 0.018 90 90 90 95 90 --                                                     11 0.070 -- 95 90 95 90 --                                                     12 0.035 80 100 70 100 80 --                                                   13 0.018 85 98 85 98 80 --                                                     14 0.018 90 98 85 95 80 --                                                     15 0.035 88 98 80 99 80 --                                                     16 0.28 90 -- 80 90 80 --                                                      17 0.28 80 -- 75 100 85 --                                                     18 0.035 85 99 90 90 90 --                                                     19 0.009 70 -- 70 95 85 --                                                     21 0.28 -- -- 95 98 90 --                                                      22 0.14 90 90 90 95 98 --                                                      23 0.035 -- -- 90 99 85 --                                                     24 0.035 75 98 90 90 85 --                                                     25 0.14 80 98 85 98 70 --                                                      26 0.018 75 95 80 85 85 --                                                     27 0.070 85 100 80 95 90 --                                                    28 0.009 60 100 75 80 80 --                                                    29 0.28 78 90 90 85 85 --                                                      30 0.070 30 95 90 98 90 --                                                     31 0.14 65 100 75 100 85 --                                                    32 0.28 70 -- 95 95 80 --                                                      33 0.14 70 100 85 95 78 --                                                     34 0.018 75 78 90 80 85 --                                                     35 0.28 95 98 80 90 90 --                                                      36 0.14 50 100 90 90 80 --                                                     37 0.035 65 90 80 75 85 --                                                     38 0.14 75 85 90 85 90 80                                                      39 0.009 78 95 80 80 78 --                                                     40 0.14 85 98 90 95 95 --                                                      41 0.070 75 100 90 90 90 --                                                    42 0.035 80 90 90 90 90 --                                                     43 0.14 90 100 90 95 95 --                                                     44 0.14 90 90 90 100 95 --                                                     45 0.28 95 100 90 100 90 --                                                    46 0.14 70 85 90 75 90 --                                                      47 0.035 70 80 90 90 78 --                                                     48 0.28 80 80 75 75 85 --                                                      50 0.005 75 95 80 65 78 78                                                     51 0.070 70 78 75 70 78 --                                                     52 0.070 90 -- 80 95 100 80                                                    53 0.070 55 75 50 65 55 --                                                     54 0.070 75 100 90 90 90 --                                                    56 0.14 70 90 90 95 75 80                                                      57 0.28 20 85 50 30 50 75                                                      58 0.28 65 100 75 65 85 80                                                     59 0.035 90 100 85 100 95 85                                                   60 0.035 85 100 78 90 80 90                                                    61 0.28 45 78 85 65 90 20                                                      62 0.070 85 100 80 85 85 95                                                    63 0.070 50 78 90 85 75 85                                                     64 0.14 100 60 95 60 65 78                                                     65 0.035 70 90 70 98 85 80                                                     66 0.14 10 99 50 100 90 70                                                     67 0.28 80 100 90 100 90 90                                                    68 0.070 10 95 85 95 85 80                                                     69 0.14 100 50 20 60 65 50                                                     70 0.035 70 80 85 80 75 78                                                     71 0.14 80 90 90 95 90 85                                                      72 0.070 60 90 60 90 80 90                                                     74 0.018 75 95 80 98 80 88                                                     83 0.070 100 100 90 95 90 --                                                   84 0.070 78 85 90 100 90 --                                                    85 0.070 75 80 85 95 90 85                                                     99 0.14 78 95 90 85 80 --                                                      100 0.28 80 100 90 85 78 --                                                    101 0.28 0 90 0 65 40 --                                                       102 0.28 45 95 78 95 75 --                                                     104 0.28 65 -- 70 -- 80 85                                                     105 0.070 90 99 85 98 95 --                                                    106 0.018 75 95 65 98 65 --                                                    107 0.28 70 90 75 95 20 --                                                     108 0.070 75 100 75 100 75 --                                                  109 0.28 85 98 85 95 85 --                                                     110 0.28 75 98 85 98 90 --                                                     111 0.035 90 98 65 95 78 --                                                    112 0.070 70 100 50 95 50 --                                                   113 0.28 0 50 0 70 20 --                                                       114 0.070 90 95 80 95 80 --                                                    115 0.28 55 100 0 95 50 --                                                     116 0.28 70 90 70 90 78 --                                                     117 0.28 80 -- 80 95 90 --                                                     118 0.070 30 100 75 100 90 --                                                  119 0.28 78 -- 50 90 60 --                                                     120 0.28 80 100 80 95 100 --                                                   121 0.14 70 100 90 95 85 --                                                    122 0.28 80 100 90 100 85 --                                                   123 0.070 80 -- 85 95 90 --                                                    124 0.29 70 100 65 100 70 --                                                   125 0.28 75 80 50 95 80 --                                                     126 0.28 78 100 90 100 85 --                                                   127 0.14 90 100 90 90 85 90                                                    129 0.035 78 -- 78 95 70 80                                                    130 0.28 65 95 75 90 80 80                                                     134 0.035 65 100 78 98 78 --                                                   135 0.28 85 -- 90 100 90 --                                                    136 0.14 80 99 85 95 90 --                                                     137 0.28 55 55 20 78 75 --                                                     141 0.14 78 90 40 90 80 80                                                     143 0.28 90 -- 90 95 90 --                                                     144 0.28 30 -- 35 90 78 --                                                     145 0.28 20 70 50 78 75 --                                                     151 0.28 55 90 45 70 70 65                                                     158 0.14 85 100 80 100 85 85                                                   159 0.14 80 98 80 95 85 90                                                     162 0.28 90 90 50 100 80 55                                                    163 0.070 100 100 50 100 65 85                                                 164 0.14 80 95 80 100 85 85                                                    165 0.14 90 85 75 90 758 5                                                     168 0.070 95 98 75 100 100 95                                                  172 0.070 80 85 75 90 80 80                                                    175 0.14 70 45 60 100 70 78                                                    177 0.070 95 100 80 100 90 80                                                  181 0.14 80 80 70 35 65 75                                                     182 0.070 90 85 90 90 80 80                                                    183 0.14 80 100 30 98 75 40                                                    184 0.35 80 98 80 95 85 85                                                     185 0.035 90 100 75 100 95 80                                                  186 0.14 75 90 75 100 80 75                                                    187 0.035 80 90 75 100 80 80                                                   188 0.028 95 100 75 100 95 80                                                  189 0.14 75 85 70 100 75 50                                                    191 0.07 85 100 85 98 75 85                                                    192 0.14 75 60 45 100 65 60                                                    193 0.14 75 85 55 100 70 78                                                    194 0.070 95 95 80 100 90 85                                                   195 0.070 80 90 70 95 75 70                                                    196 0.018 80 75 45 80 75 75                                                    197 0.009 78 80 75 90 80 80                                                    198 0.035 75 100 80 100 80 90                                                  199 0.070 80 90 80 100 90 80                                                   200 0.035 75 95 80 80 90 85                                                    201 0.070 75 80 70 100 80 78                                                   202 0.14 90 100 70 100 90 70                                                   203 0.070 70 100 70 100 70 60                                                  204 0.14 95 100 90 95 70 90                                                    205 0.14 98 95 85 98 85 80                                                     206 0.14 80 95 70 80 80 75                                                     208 0.070 100 100 75 100 85 95                                                 210 0.14 90 90 80 80 75 80                                                     211 0.14 75 95 80 100 80 75                                                    212 0.035 75 100 65 100 75 80                                                  216 0.035 75 85 65 75 79 80                                                    218 0.070 80 90 90 100 75 85                                                 __________________________________________________________________________     Cpd.                                                                               Rate,                                                                        No. Kg/Ha GWBLG GWBRN GWCRB GWGFT GWROX GWWOT                                __________________________________________________________________________       1 0.28 60 40 -- 95 -- 70                                                       2 0.28 70 100 -- 95 -- 60                                                      3 0.28 0 70 -- 50 -- 30                                                        4 0.28 0 60 -- 90 -- 0                                                         5 0.14 75 90 85 95 95 80                                                       6 0.14 90 90 -- 90 -- 60                                                       7 0.14 80 70 -- 60 -- 50                                                       8 0.14 40 70 -- 30 -- 50                                                       9 0.14 70 90 -- 80 -- 50                                                       10 0.018 100 100 100 95 100 85                                                 11 0.070 70 90 95 80 98 50                                                     12 0.035 90 90 90 98 95 70                                                     13 0.018 95 98 100 98 100 90                                                   14 0.018 98 98 95 95 98 98                                                     15 0.035 98 95 95 95 95 95                                                     16 0.28 75 80 50 75 90 50                                                      17 0.28 80 98 98 95 100 85                                                     18 0.035 95 99 95 90 98 75                                                     19 0.009 95 78 90 85 95 80                                                     21 0.28 90 95 -- 95 -- 90                                                      22 0.14 95 90 98 90 100 80                                                     23 0.035 95 98 -- 95 -- 98                                                     24 0.035 85 90 85 85 99 80                                                     25 0.14 85 80 80 90 100 90                                                     26 0.018 90 95 95 90 100 90                                                    27 0.070 90 98 95 95 100 80                                                    28 0.009 90 90 90 78 90 85                                                     29 0.28 78 78 55 55 90 55                                                      30 0.070 90 80 95 85 95 80                                                     31 0.14 100 95 100 95 100 95                                                   32 0.28 -- 70 60 80 95 80                                                      33 0.14 -- 90 95 85 95 90                                                      34 0.018 90 70 98 78 90 80                                                     35 0.28 80 85 70 75 95 80                                                      36 0.14 90 90 100 90 100 80                                                    37 0.035 90 98 78 98 100 90                                                    38 0.14 95 65 70 70 100 90                                                     39 0.009 95 65 55 65 70 98                                                     40 0.14 95 100 80 90 100 90                                                    41 0.070 85 100 100 95 100 98                                                  42 0.035 90 95 65 80 70 78                                                     43 0.14 65 78 55 90 78 70                                                      44 0.14 80 80 65 90 85 80                                                      45 0.28 80 95 70 95 85 80                                                      46 0.14 78 98 70 80 70 78                                                      47 0.035 85 90 95 90 98 90                                                     48 0.28 75 75 65 78 9B 80                                                      50 0.005 95 85 78 65 85 90                                                     51 0.070 100 85 70 90 100 90                                                   52 0.070 95 95 60 60 78 78                                                     53 0.070 100 95 45 75 100 95                                                   54 0.070 100 100 90 95 95 85                                                   56 0.14 95 95 65 60 100 80                                                     57 0.28 70 40 0 55 60 60                                                       58 0.28 100 95 50 75 100 95                                                    59 0.035 90 90 78 90 100 90                                                    60 0.035 90 100 65 80 100 85                                                   61 0.28 65 20 35 35 90 50                                                      62 0.070 80 100 55 85 100 90                                                   63 0.070 90 70 65 85 95 80                                                     64 0.14 60 55 20 55 95 70                                                      65 0.035 95 98 100 90 99 80                                                    66 0.14 85 90 100 70 95 90                                                     67 0.28 95 95 65 90 100 80                                                     68 0.070 95 75 100 95 95 80                                                    69 0.14 20 45 40 55 60 20                                                      70 0.035 95 100 70 75 90 75                                                    71 0.14 90 80 60 65 90 85                                                      72 0.070 95 85 100 90 100 90                                                   74 0.018 95 95 75 78 95 85                                                     83 0.070 85 95 95 90 100 85                                                    84 0.070 98 95 80 90 95 90                                                     85 0.070 90 85 80 55 95 80                                                     99 0.14 95 95 78 85 90 85                                                      100 0.28 78 80 80 80 90 70                                                     101 0.28 40 0 0 20 0 0                                                         102 0.28 75 55 70 90 80 50                                                     104 0.28 45 65 60 -- 75 75                                                     105 0.070 95 90 95 95 98 90                                                    106 0.018 98 93 90 60 90 88                                                    107 0.28 90 80 50 75 85 85                                                     108 0.070 90 95 85 70 95 85                                                    109 0.28 75 95 70 60 95 70                                                     110 0.28 75 85 75 78 90 80                                                     111 0.035 90 90 70 78 98 85                                                    112 0.070 85 90 20 40 90 80                                                    113 0.28 50 0 0 20 60 0                                                        114 0.070 90 95 95 95 95 80                                                    115 0.28 85 70 20 50 90 40                                                     116 0.28 95 78 40 78 95 85                                                     117 0.28 -- 90 78 85 95 80                                                     118 0.070 90 90 95 85 98 90                                                    119 0.28 -- 78 45 40 95 80                                                     120 0.28 -- 85 80 78 95 85                                                     121 0.14 90 90 95 90 98 85                                                     122 0.28 90 98 90 80 100 80                                                    123 0.070 -- 98 95 90 98 90                                                    124 0.29 80 90 30 60 100 50                                                    125 0.28 85 65 60 20 100 78                                                    126 0.28 78 95 80 70 100 50                                                    127 0.14 100 95 95 90 100 80                                                   129 0.035 100 95 70 55 100 90                                                  130 0.28 90 78 30 60 95 70                                                     134 0.035 90 90 85 90 95 85                                                    135 0.28 50 95 65 78 100 65                                                    136 0.14 90 90 95 95 95 80                                                     137 0.28 95 75 30 80 100 80                                                    141 0.14 90 95 95 90 95 95                                                     143 0.28 90 85 95 98 100 90                                                    144 0.28 60 65 80 78 85 70                                                     145 0.28 55 65 20 60 80 70                                                     151 0.28 95 65 80 98 95 60                                                     158 0.14 100 100 95 100 100 75                                                 159 0.14 100 85 98 100 100 85                                                  162 0.28 75 75 55 40 70 55                                                     163 0.070 85 80 75 85 90 75                                                    164 0.14 100 100 85 100 100 85                                                 165 0.14 95 75 75 90 100 85                                                    168 0.070 95 90 20 85 75 55                                                    172 0.070 85 85 75 100 75 --                                                   175 0.14 100 60 40 50 100 70                                                   177 0.070 75 100 80 90 70 70                                                   181 0.14 85 40 60 60 85 --                                                     182 0.070 95 85 50 65 85 --                                                    183 0.14 100 100 100 100 100 --                                                184 0.35 70 90 65 85 65 75                                                     185 0.035 75 75 70 100 70 55                                                   186 0.14 85 75 65 100 100 70                                                   187 0.035 70 90 65 85 70 30                                                    188 0.028 80 75 65 60 85 45                                                    189 0.14 60 55 30 65 60 50                                                     191 0.07 100 100 95 100 100 100                                                192 0.14 85 70 30 35 90 80                                                     193 0.14 100 70 45 60 100 95                                                   194 0.070 45 80 60 75 80 45                                                    195 0.070 70 100 70 100 60 70                                                  196 0.018 100 75 70 100 85 95                                                  197 0.009 100 98 100 100 100 100                                               198 0.035 100 85 75 100 100 90                                                 199 0.070 75 75 60 75 70 55                                                    200 0.035 90 85 95 80 98 98                                                    201 0.070 100 100 75 100 100 95                                                202 0.14 90 90 60 50 50 70                                                     203 0.070 95 90 70 85 90 80                                                    204 0.14 -- 95 -- 100 95 100                                                   205 0.14 80 75 0 70 75 70                                                      206 0.14 75 60 0 55 80 70                                                      208 0.070 80 100 70 75 70 65                                                   210 0.14 45 70 50 45 70 55                                                     211 0.14 60 80 50 85 60 30                                                     212 0.035 -- 75 98 100 100 75                                                  216 0.035 100 85 80 100 100 95                                                 218 0.070 95 70 98 100 100 --                                                __________________________________________________________________________      BWLMQ = lambsguarters (Chenopodium album)                                      BWPIG = pigweed (Amaranthus retroflexus)                                       GWBLG = blackgrass (Alopecurus myosuroides)                                    GWROX = Rox orange sorghum (Sorghum bicolor)                                   BWCKB = cocklebur (Xanthium struinarium)                                       BWMGL = morningglory (Ipomoea hederacea)                                       BWVEL = velvetleaf (Abutilion theophrasti)                                     GWGFT = giant foxtail (Setaria faberi)                                         GWWOT = wild oats (Avena fatua)                                                GBCRB = crabgrass (Digitaria sanguinalis)                                      GWBRN = barnyardgrass (Echinochloa crusgalli)                                  BWWPT = wild poinsettia (Euphorbia heterophylla)                          

What is claimed is:
 1. A pyridine-3-sulfonyl chloride compound of the formula: ##STR13## wherein A represents H, F, Cl, Br, or I, or CO₂ (C₁ -C₄ alkyl) or represents C₁ -C₃ alkyl, O(C₁ -C₄ alkyl), O(C₃ -C₄ alkenyl), O(C₃ -C₄ alkynyl), or S(C₁ -C₃ alkyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms;B represents H, F, Cl, Br, I, NO₂, CN, CO₂ (C₁ -C₄ alkyl), NH(C₁ -C₃ alkyl), or N(C₁ -C₃ alkyl)₂ or represents O(C₁ -C₄ alkyl), O(C₃ -C₄ alkenyl), O(C₃ -C₄ alkynyl), C₁ -C₃ alkyl, S(C₁ -C₃ alkyl), SO(C₁ -C₃ alkyl), SO₂ (C₁ -C₃ alkyl), S(C₃ -C₄ alkenyl), SO(C₃ -C₄ alkenyl), SO₂ (C₃ -C₄ alkenyl), S(C₃ -C₄ alkynyl), SO(C₃ -C₄ alkynyl), or SO₂ (C₃ -C₄ alkynyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms; with the proviso that at least one of A and B represents O(C₁ -C₄ alkyl), O(C₃ -C₄ alkenyl), or O(C₃ -C₄ alkynyl) each optionally substituted with one O(C₁ -C₃ alkyl), S(C₁ -C₃ alkyl), chloro, bromo, or cyano substituent or with up to the maximum possible number of fluorine atoms; and D represents H, F, Cl, Br, I, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ F, CHF₂, or CF₃.
 2. A compound according to claim 1 wherein A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, 1-(fluoromethyl)-2-fluoroethoxy, trifluoromethoxy, chloro, or fluoro; B represents, methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethyl, methylthio, methyl, trifluoromethyl, trifluoromethoxy, fluoro, chloro, or methoxycarbonyl, and, when A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, 1-(fluoromethyl)-2-fluoroethoxy or trifluoromethoxy, hydrogen; and D represents hydrogen, fluoro, chloro, bromo, or methyl.
 3. A compound according to claim 2 wherein B represents methoxy and D represents hydrogen; wherein A represents methoxy and D represents hydrogen, methyl, or chloro; or wherein B represents trifluoromethyl and D represents hydrogen.
 4. A compound according to claim 2 wherein A represents methoxy, ethoxy, propoxy, 1-methylethoxy, methoxymethoxy, methoxyethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy, or 1-(fluoromethyl)-2-fluoroethoxy; B represents hydrogen, methoxy, ethoxy, propoxy, 1-methylethoxy, trifluoromethyl, or methoxycarbonyl; and D represents hydrogen or methyl.
 5. A compound according to claim 4 wherein A represents methoxy and B represents trifluoromethyl. 